Process development for recovery and purification of exosomes for regenerative therapy

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Exosomes are emerging as a novel therapeutic candidate with potential to treat multiple indications. ReNeuron and UCL have a strong track record of collaborating in the area of exosome manufacture and we have delivered significant advancement for manufacturing exosomes via an Innovate UK grant and an existing EngD project. However, whilst we have explored options for recovery and purification of exosomes and made significant advancement in the upstream cell culture, there is still work needed to enhance purity of specific exosome subpopulations and to make meaningful measurements of the resulting product. Building on chromatographic methods already developed at UCL to remove process impurities, we will make further advancement towards a regulatory approved product, via enhanced polishing and new quantity and quality measurements. Specifically, we will aim to advance purification technology and measurement tools for high-purity recovery of exosome subpopulations from stem cells.