Development and optimization of downstream process for recovery of natural aldehydes from fermentation media

从发酵培养基中回收天然醛的下游工艺的开发和优化

基本信息

批准号：
538618-2019
负责人：
Williamson, Vanessa
金额：
$ 1.82万
依托单位：
Seneca College of Applied Arts and Technology
依托单位国家：
加拿大
项目类别：
Applied Research and Development Grants - Level 1
财政年份：
2019
资助国家：
加拿大
起止时间：
2019-01-01 至 2020-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680468
关键词：
Development optimization downstream process recovery

项目摘要

Ardra Inc. is a biotechnology company that manufactures high-purity natural ingredients sustainably, which are suitable for use in natural flavours, perfumery and cosmetics formulations. Ardra's products, produced using fermentation of natural sugars, offer significant cost and sustainability advantages over traditional plant-based extractions. Additionally, since the products do not rely on botanical raw material, their supply is stable and devoid of seasonal variations. One difficulty in fermentation to produce these chemicals is the efficient and high-purity isolation of the desired product from the mixture of fermentation byproducts after fermentation is complete. As a result, Ardra is collaborating with Professor Jamie Cote and Professor David Guevara, from the School of Biological Sciences and Applied Chemistry (SBSAC) at Seneca. Professor Cote has over 5 years of experience in separations and purifications or organic chemicals and pharmaceuticals, and Professor Guevara has over 10 years of experience in natural products separations and analysis. Along with their research assistants from SBSAC, Professor Cote and Guevara will work closely with Ardra to understand the existing purification process and design and optimize a new purification procedure that will be more cost effective, but also provide a higher-purity product with less waste than the existing method. This resulting process will be directly implemented into Ardra's production line to provide immediate benefit to the company.

Ardra Inc.是一家生物技术公司，可持续生产高纯度天然成分，适用于天然风味，香水和化妆品配方。 Ardra的产品使用天然糖的发酵生产，比传统的基于植物的提取物具有很大的成本和可持续性优势。此外，由于产品不依赖植物原料，因此它们的供应稳定且没有季节性变化。发酵产生这些化学物质的一个困难是从发酵副产物的混合物中进行了有效，高纯度分离。结果，Ardra与塞内卡（Seneca）生物科学与应用化学学院（SBSAC）的杰米·科特（Jamie Cote）和戴维·格瓦拉（David Guevara）教授合作。 Cote教授在分离和净化或有机化学和药品方面拥有超过5年的经验，而Guevara教授在天然产品分离和分析方面拥有10多年的经验。除了SBSAC的研究助理外，Cote和Guevara教授将与Ardra紧密合作，以了解现有的纯化过程和设计，并优化了一种更具成本效益的新纯化程序，但也提供了比现有方法更少的浪费更高的纯耐受性产品。这一过程将直接实施到Ardra的生产线中，以为公司提供直接利益。