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Development and optimization of downstream process for recovery of natural aldehydes from fermentation media

从发酵培养基中回收天然醛的下游工艺的开发和优化

基本信息

批准号：
538618-2019
负责人：
Williamson, Vanessa
金额：
$ 1.82万
依托单位：
Seneca College of Applied Arts and Technology
依托单位国家：
加拿大
项目类别：
Applied Research and Development Grants - Level 1
财政年份：
2019
资助国家：
加拿大
起止时间：
2019-01-01 至 2020-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680468
关键词：
Development optimization downstream process recovery

项目摘要

Ardra Inc. is a biotechnology company that manufactures high-purity natural ingredients sustainably, which are suitable for use in natural flavours, perfumery and cosmetics formulations. Ardra's products, produced using fermentation of natural sugars, offer significant cost and sustainability advantages over traditional plant-based extractions. Additionally, since the products do not rely on botanical raw material, their supply is stable and devoid of seasonal variations. One difficulty in fermentation to produce these chemicals is the efficient and high-purity isolation of the desired product from the mixture of fermentation byproducts after fermentation is complete. As a result, Ardra is collaborating with Professor Jamie Cote and Professor David Guevara, from the School of Biological Sciences and Applied Chemistry (SBSAC) at Seneca. Professor Cote has over 5 years of experience in separations and purifications or organic chemicals and pharmaceuticals, and Professor Guevara has over 10 years of experience in natural products separations and analysis. Along with their research assistants from SBSAC, Professor Cote and Guevara will work closely with Ardra to understand the existing purification process and design and optimize a new purification procedure that will be more cost effective, but also provide a higher-purity product with less waste than the existing method. This resulting process will be directly implemented into Ardra's production line to provide immediate benefit to the company.

Ardra Inc.是一家可持续生产高纯度天然成分的生物技术公司，这些成分适合用于天然香料、香水和化妆品配方。Ardra的产品使用天然糖发酵生产，与传统的植物提取物相比，提供了显著的成本和可持续性优势。此外，由于产品不依赖于植物原料，其供应稳定，没有季节性变化。生产这些化学品的发酵的一个困难是在发酵完成后从发酵副产物的混合物中有效地和高纯度地分离出所需的产品。因此，ARDRA正在与来自Seneca生物科学和应用化学学院(SBSAC)的Jamie Cote教授和David Guevara教授合作。Cote教授在分离和提纯或有机化学品和制药方面拥有5年以上的经验，而Guevara教授在天然产品分离和分析方面拥有10年以上的经验。Cote教授和Guevara教授将与他们来自SBSAC的研究助理密切合作，了解现有的净化工艺，并设计和优化一种新的净化工艺，该工艺将更具成本效益，并提供比现有方法更少浪费的更高纯度的产品。这一过程将直接应用到Ardra的生产线上，为公司带来立竿见影的好处。