雪旺细胞、神经营养因子和脊髓再生-猫眼课题宝

雪旺细胞、神经营养因子和脊髓再生

批准号：

6539925

负责人：

XIAO XU

金额：

$17.32万

依托单位：

UNIVERSITY OF LOUISVILLE

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-05-15 至 2003-06-30

来源：

https://reporter.nih.gov/project-details/6539925

关键词：

Schwann cells biological models drug delivery systems fibroblast growth factor insulinlike growth factor methylprednisolone nervous system regeneration neurotrophic factors spinal cord injury transforming growth factors

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中文摘要

翻译

本应用程序的基本目标是利用的半切模型

英文摘要

The basic goal of this application is to utilize a hemisection model of the spinal cord in which a gap is created and a mini-guidance channel filled with Schwann cells is inserted. In addition, the model incorporates two additional elements that are intended to maximize the elongation of regenerating axons into the distal cord. These are the administration of methylprednisilone plus the slow release of various neurotrophins via an osmotic mini-pump just caudal to the bridge. Taken together the specific aims of this model could be described as one with a most comprehensive attempt to maximize regeneration into the host cord tissue caudal to a Schwann cell bridged lesion.

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