SCHWANN CELLS, NEUROTROPHINS AND SPINAL CORD REGROWTH

本申请的基本目标是利用半切模型， 其中产生间隙的脊髓和微型引导通道 填充有许旺细胞的细胞被插入。 此外，模型 结合了两个额外的元素，旨在最大限度地提高 再生轴突延伸到远端索中。 这些都是 给予甲基强的松龙加缓释各种 神经营养素通过渗透微型泵只是尾部的桥梁。 采取 这一模式的具体目标可以被描述为 一个最全面的尝试，最大限度地再生到宿主脊髓， 雪旺氏细胞桥接病变尾部的组织。

The basic goal of this application is to utilize a hemisection model of the spinal cord in which a gap is created and a mini-guidance channel filled with Schwann cells is inserted. In addition, the model incorporates two additional elements that are intended to maximize the elongation of regenerating axons into the distal cord. These are the administration of methylprednisilone plus the slow release of various neurotrophins via an osmotic mini-pump just caudal to the bridge. Taken together the specific aims of this model could be described as one with a most comprehensive attempt to maximize regeneration into the host cord tissue caudal to a Schwann cell bridged lesion.