SCHWANN CELLS, NEUROTROPHINS AND SPINAL CORD REGROWTH

雪旺细胞、神经营养因子和脊髓再生

• 批准号: 6539925
• 负责人: XIAO XU
• 金额: $ 17.32万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6539925
• 关键词: Schwann cells; biological models; drug delivery systems; fibroblast growth factor; insulinlike growth factor; methylprednisolone; nervous system regeneration; neurotrophic factors; spinal cord injury; transforming growth factors

The basic goal of this application is to utilize a hemisection model of the spinal cord in which a gap is created and a mini-guidance channel filled with Schwann cells is inserted. In addition, the model incorporates two additional elements that are intended to maximize the elongation of regenerating axons into the distal cord. These are the administration of methylprednisilone plus the slow release of various neurotrophins via an osmotic mini-pump just caudal to the bridge. Taken together the specific aims of this model could be described as one with a most comprehensive attempt to maximize regeneration into the host cord tissue caudal to a Schwann cell bridged lesion.

本应用程序的基本目标是利用的半切模型