Effects of a Novel Hotspot Mutation of Brm in Non-Melanoma Skin Cancer Development

Brm 的新热点突变对非黑色素瘤皮肤癌发展的影响

• 批准号: nhmrc : 1017798
• 负责人: Mr Andrew Farrell
• 金额: $ 6.16万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-novel-hotspot-cancer-development/109914
• 关键词: Effects; Novel; Hotspot; Mutation; Brm

Australia has the highest incidence of skin cancer in the world. SWI/SNF, a yeast nucleosome remodeling complex, is known destabilise interactions in DNA. It is made up of 8-10 proteins, including a novel tumour suppressor Brm. There is some evidence that Brm acts as a tumour suppressor in skin cancer, but relevance of a recently found mutation in Brm is yet to be characterised. This project aims to identify the effect of this mutation, on cellular sensitivity to UV radiation and examine transformation to malignancy.

澳大利亚是世界上皮肤癌发病率最高的国家。SWI/SNF是一种酵母核小体重塑复合物，已知会破坏DNA相互作用的稳定性。它由8-10种蛋白质组成，包括一种新的肿瘤抑制因子Brm。有一些证据表明，Brm在皮肤癌中起肿瘤抑制剂的作用，但最近发现的Brm突变的相关性尚未得到表征。该项目旨在确定这种突变对细胞对紫外线辐射的敏感性的影响，并检查转化为恶性肿瘤。