SPATIAL ANALYSIS IN CHILDREN WITH FOCAL BRAIN INJURY

描述：建议的研究，五年前瞻性纵向研究 研究的目的是考察空间分析的早期发展，这是 被认为涉及指定部件、配置和 部件和配置的集成。具体目标是：1) 定义与早期损伤相关的缺陷模式；2)查看 用于实时空间分析的反应时间研究；3)检查 早期病灶后这些技能的纵向发展模式 损伤；4)观察跨域空间加工；4)扩展 通过应用功能磁共振成像方案来检查神经模式的先前工作 在空间分析处理中的激活。三种认知行为 提出了一项研究和一项功能磁共振研究。这项研究旨在延长 申请者之前的发现显示了左侧和右侧 儿童早期获得性脑损害具有相似的空间模式 对患有后天性左侧或右侧病变的成年人进行缺陷分析。这个 来自拟议研究的新信息将涉及到对 按脑区划分的额外空间分析任务，以比较 空间信息的构建和感知，以及对空间信息的审查 早期局灶性损伤后神经组织的差异。

DESCRIPTION: The proposed research, a five-year prospective longitudinal study, aims to examine the early development of spatial analysis, which is considered to involve the ability to specify the parts, configuration, and the integration of parts and configurations. The specific aims are: 1) to define patterns of deficit associated with early injury; 2) to look at reaction time studies for spatial analysis in real time; 3) to examine longitudinal patterns of development in these skills after early focal injury; 4) to look at cross-domain spatial processing; and 4) to extend previous work by applying an fMRI protocol for examining patterns of neural activation in spatial analytic processing. Three cognitive-behavioral studies and one fMRI study are proposed. The studies aims to extend the previous findings from the applicants showing left and right-sided early-acquired brain lesions in children to have similar pattern of spatial analysis deficits to adults with later-acquired left or right lesions. The new information from the proposed research would concern description of extra spatial analysis tasks by brain region, with a view to comparing construction and perception of space information, and the examination of differences in neural organization following early focal injury.