CRYSTAL STRUCTURE OF STAT4 N TERMINAL DOMAIN

我们收集了一个优秀的数据集从晶体的双重 特异性磷酸酶VHR与钒酸盐复合。 数据 至少1.6倍
，并且具有3.5%至1.8%的Rsym
.这 结构最近已经解决，并提供了深入了解 磷酸盐水解的过渡态。 一些数据集也 从LAR受体酪氨酸的催化结构域收集 磷酸酶。 从抗DNA Fab的冷冻晶体收集的数据 片段现在被用来改进这种抗体的结构。

We collected an outstanding data set from a crystals of the dual specificity phosphatase VHR complexed with vanadate. The data extended to at least 1.6
, and had an Rsym of 3.5% to 1.8
. This structure recently has been solved and provides insights into the transition state of phosphate hydrolysis. Several data sets were also collected from the catalytic domain of the LAR receptor tyrosine phosphatase. Data collected from frozen crystals of an anti-DNA Fab fragment are now being used to refine the structure of this antibody.