ROLE OF OXYGEN IN DEVELOPMENT OF ECHINODERM EMBRYO
氧气在棘皮动物胚胎发育中的作用
基本信息
- 批准号:6414918
- 负责人:
- 金额:$ 21.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-12-01 至 2001-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The oxygen-selective self-referencing probe is being used to test
if differences in oxygen availa-bility within a microscopic
preparation are responsible for observed inhibition in embryo
develop-ment. The experiments are using a classic model of
developmental organization, the echninoderm ooyte and embryo and
follow observations by Inoue that embryo position, in a confluent
mass, causes asynchronous growth. The initial research has been
oriented toward documenting the changes in oxygen flux into
unfertilized eggs and embryos, and seeing how oxygen consumption
changes as the embryo develops. To date we have been able to show
that a significant increase in the oxygen influx is associated with
the fertilization process. Furthermore, we have been able to measure
the kinetics of these changes in real time. While experiments are in
the early stages, this system has shown much promise for further
research. The echinoderm system is extremely easy to work with.
Millions of gametes can be obtained from a single animal and these
gametes remain viable for hours in seawater at room temperature.
Therefore, oocyte fertilization and zygote formation can be initiated
at the convenience of the investigator and the exact time can be
noted. The studies documenting changes in oxygen consumption in mouse
embryos is complemented by this research. It will undoubtedly be
valuable to compare the findings from these. The starfish embryo
develops in reasonably well oxygenated waters whereas the mouse embryo
develops in the hypoxic uterine environment. Overall these studies
will contribute to our understanding of the metabolic changes
associated with early embryonic development.
氧选择性自参考探针被用于测试
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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D M PORTERFIELD其他文献
D M PORTERFIELD的其他文献
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{{ truncateString('D M PORTERFIELD', 18)}}的其他基金
PROGRESS W/ SELF REFERENCING POLAROGRAPHIC ELECTRODES
自参考极谱电极的进展
- 批准号:
6568418 - 财政年份:2001
- 资助金额:
$ 21.13万 - 项目类别:
ROLE OF OXYGEN IN DEVELOPMENT OF ECHINODERM EMBRYO
氧气在棘皮动物胚胎发育中的作用
- 批准号:
6568414 - 财政年份:2001
- 资助金额:
$ 21.13万 - 项目类别:
PROGRESS W/ SELF REFERENCING POLAROGRAPHIC ELECTRODES
自参考极谱电极的进展
- 批准号:
6414922 - 财政年份:2000
- 资助金额:
$ 21.13万 - 项目类别:
DEVELOPMENT OF SELF REFERENCING ELECTROCHEMICAL MICROSENSORS NITRIC OXIDE
自参考电化学一氧化氮微型传感器的研制
- 批准号:
6120169 - 财政年份:1998
- 资助金额:
$ 21.13万 - 项目类别:
DEVELOPMENT OF SELF REFERENCING ELECTROCHEMICAL MICROSENSORS OXYGEN
自参考电化学微型氧气传感器的研制
- 批准号:
6120168 - 财政年份:1998
- 资助金额:
$ 21.13万 - 项目类别:
DEVELOPMENT OF SELF REFERENCING ELECTROCHEMICAL MICROSENSORS ASCORBIC ACID
自参考电化学抗坏血酸微型传感器的研制
- 批准号:
6120170 - 财政年份:1998
- 资助金额:
$ 21.13万 - 项目类别:
PROGRESS W/ SELF REFERENCING POLAROGRAPHIC ELECTRODES
自参考极谱电极的进展
- 批准号:
6281108 - 财政年份:1997
- 资助金额:
$ 21.13万 - 项目类别:
ROLE OF OXYGEN IN DEVELOPMENT OF ECHINODERM EMBRYO
氧气在棘皮动物胚胎发育中的作用
- 批准号:
6281125 - 财政年份:1997
- 资助金额:
$ 21.13万 - 项目类别: