Network asymmetry, callosal development and autistic behaviour

网络不对称、胼胝体发育和自闭症行为

• 批准号: 1931759
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1931759
• 关键词: Network; asymmetry; callosal; development; autistic

This study aims to integrate information from human imaging and mouse models to test the hypothesis that deficits in the corpus callosum (CC) can impact the development of association white matter (WM), and that such deficits occur in Autism Spectrum Disorder (ASD). It aims to test: in mouse-models(1) if non-typical development of the CC disrupts development of association WM pathways(2) if CC deficits correlate with ASD-like phenotypes (using mice with mutations in ASD candidate genes) in primates, including developing humans and adults with ASD(3) if species-specific CC differences exist between Macaque/Vervet monkeys, Chimpanzees and Humans(4) if CC microstructural anatomy is linked to normal asymmetry development of association pathways involved inlanguage and social cognition(5) if deficits of the CC correlate with those in association WM pathways(6) if such deficits correlate with symptoms

这项研究的目的是整合人类成像和小鼠模型的信息，以验证这样的假设，即痂状体(CC)的缺陷可以影响关联性白质(WM)的发育，并且这种缺陷发生在自闭症谱系障碍(ASD)中。它的目的是在小鼠模型中测试：(1)CC的非典型发育是否扰乱了关联WM通路的发展(2)CC缺陷是否与灵长类动物(包括发育中的人类和患有ASD的成年人)的ASD样表型相关(使用ASD候选基因突变的小鼠)(3)如果猕猴/长尾猴、黑猩猩和人类之间存在物种特异性的CC差异(4)CC的微结构解剖是否与正常的不对称发展有关(5)如果CC缺陷与关联WM通路中的关联WM通路的发育相关(5)如果CC缺陷与症状相关(6)