Promoting and Controlling Vascularisation in Engineered Tissues

促进和控制工程组织中的血管化

• 批准号: 1931832
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1931832
• 关键词: Promoting; Controlling; Vascularisation; Engineered; Tissues

Research Area: Biomaterials and tissue engineeringMethods of vascularisation of engineered tissue have long been sought after to enable inosculation with host vessels and prevent hypoxia after implantation. Despite some successes, methods remain very much driven by trial and error in order to optimise the combination and ratio of cell types, fluid flow and the quantities of angiogenic factors, to obtain a fully perfusable and stable vascular network. The aim of this project is to use computational modelling, in conjunction with experiments, to model vasculogenesis and, in turn, answer some of the complex questions regarding optimising the relevant physical parameters to ensure both short- and long-term survival of the implanted tissue. To achieve this, the project seeks to address discrepancies between existing models by incorporating other complementary mechanisms suggested in the literature. Furthermore, we seek to use computational modelling to investigate which factors play a key role in the survival and stability of the network once implanted in vivo.

研究领域：生物材料和组织工程长期以来，人们一直在寻求工程组织血管化的方法，以使其能够与宿主血管吻合并防止植入后缺氧。尽管取得了一些成功，但方法仍然在很大程度上受到试验和错误的驱动，以便优化细胞类型的组合和比例、流体流动和血管生成因子的量，以获得完全可灌注和稳定的血管网络。该项目的目的是使用计算建模，结合实验，来模拟血管生成，并反过来回答一些关于优化相关物理参数的复杂问题，以确保植入组织的短期和长期存活。为实现这一目标，该项目试图通过纳入文献中建议的其他补充机制来解决现有模式之间的差异。此外，我们试图使用计算模型来研究哪些因素在植入体内后对网络的生存和稳定性起关键作用。