University of Michigan Rheumatic Diseases Core Center

密歇根大学提议建立风湿病核心中心。这将是一项基础广泛的工作，涉及密歇根大学和邻近机构临床和基础科学部门的约80名教师。该中心将应用广泛的研究技能，背景和方法来调查风湿性疾病的病因和发病机制中的基本问题，并为新疗法开发科学基础。该中心将集中其活动，将研究人员分组为四个主要项目（创新治疗模型系统，自身免疫，器官炎症和损伤中的细胞和细胞因子相互作用，以及风湿性疾病中的基因表达的遗传学和模式）;以及疾病重点工作组（骨关节炎，银屑病/银屑病关节炎，风湿性关节炎和系统性红斑狼疮）。该中心的活动将得到六个生物医学核心设施的支持，包括流式细胞术，杂交，载体，转基因动物，蛋白质结构和DNA测序核心。UM-RDCC教师将以大幅折扣的充值费率获得风湿性疾病相关研究的核心服务。提出了两个试点和可行性项目，每个项目都由最近招募到密歇根大学的新教师领导。UM-RDCC及其行政单位将由大卫A领导。福克斯医学博士他在密歇根大学多功能关节炎和肌肉骨骼疾病中心工作了十多年，在管理一个基础广泛的中心方面经验丰富。Rory Marks医学博士流变学副教授被提议为UM-RDCC副主任，特别负责监督生物医学核心。中心领导层将保持UM-RDCC的基础研究活动与密歇根大学风湿性疾病临床研究的密切联系。该中心的行政团队将由执行委员会、内部咨询委员会和外部科学顾问Bennis卡森博士协助。我们构建了UM-RDCC，最大限度地利用密歇根大学的人才和资源，专注于风湿性疾病的基础研究，在提高对病因、发病机制和治疗的认识方面取得实质性进展。

The University of Michigan proposes to establish a Rheumatic Disease Core Center. This will be a broadly based effort involving approximately 80 faculty from clinical and basic science departments at the University of Michigan and neighboring institutions. The Center will apply a broad range of research skills, backgrounds, and approaches to investigation of fundamental issues in the etiology and pathogenesis of rheumatic diseases and in development of a scientific basis for novel therapeutics. The Center will focus its activities by grouping investigators in four Major Programs (Model Systems for Innovative Therapeutics, Autoimmunity, Cell and Cytokine Interactions in Organ Inflammation and Damage, and Genetics and Patterns of Gene Expression in the Rheumatic Diseases); and also in Disease Focused Working Groups (Osteoarthritis, Psoriasis/Psoriatic Arthritis, Rheumatoid Arthritis and Systemic Lupus Erythematosis). Activities of the Center will be supported by six Biomedical Core Facilities including Flow Cytometry, Hybridoma, Vector, Transgenic Animal, Protein Structure and DNA Sequencing Cores. UM-RDCC faculty will have access to core services for rheumatic disease-related research at substantially discounted recharge rates. Two Pilot and Feasibility Projected are proposed, each of which is led by new faculty recently recruited to the University of Michigan. The UM-RDCC and its administrative unit will be directed by David A. Fox, M.D., who is experienced in administration of a broadly based Center through more than ten years directing the University of Michigan Multipurpose Arthritis and Musculoskeletal Diseases Center. Rory Marks, M.D., Associate Professor of Rheumatology is proposed as the UM-RDCC Associate Director, with special responsibilities for supervision of the biomedical cores. The Center leadership will maintain close links between the basic research activities of the UM-RDCC and expanding clinical investigation in the rheumatic diseases at the University of Michigan. The Center's administrative team will be assisted by an Executive Committee, an Internal Advisory Committee, and an External Scientific Advisor, Dr. Bennis Carson. We have constructed the UM- RDCC to maximally engage the talents and resources of the University of Michigan to focus on basic research in the rheumatic diseases in the rheumatic diseases, so as to achieve substantial progress in improving understanding of etiology, pathogenesis and treatment.