University of Michigan Rheumatic Diseases Research Core Center

密歇根大学风湿病研究核心中心

• 批准号: 7938844
• 负责人: David Alan Fox
• 金额: $ 58.99万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7938844
• 关键词: University; Michigan; Rheumatic; Diseases; Research

The University of Michigan proposes to renew funding for its Rheumatic Diseases Research Core Center (UM-RDCC). The UM-RDCC is a broadly based effort involving approximately eighty faculty, who seek to apply a broad range of research skills, backgrounds, and approaches to investigation of fundamental issues in the etiology and pathogenesis of rheumatic diseases and in development of a scientific basis for novel therapeutics. The UM-RDCC will foster collaborations between investigators in thematic areas of research strength and interest, such as development and testing of innovative therapeutics, analysis of immune mechanisms in rheumatic diseases and investigation of organ-targeted inflammatory and tissue remodeling pathways. The UM-RDCC will also foster disease focused laboratory and translational research linked to clinical research programs. Activities in the Center will be supported by six Biomedical Core Facilities, including Flow Cytometry, Hybridoma, Vector, Transgenic Animal, Protein Structure, and Microarray. Three Pilot and Feasibility Projects are proposed, two of which are led by new faculty recently recruited to the UMRDCC, whose focus is the pathogenesis of inflammatory arthritis. The third Pilot and Feasibility Project is led by an experienced dermatology investigator who will mechanistically investigate a highly innovative approach to treating scleroderma. The UM-RDCC and its administrative unit will be directed by David A. Fox, M.D., who has fifteen years of experience in administration of broadly based, NIAMS-funded center programs. Rory Marks, M.D., Associate Professor of Rheumatology is proposed to continue as the UMRDCC Associate Director, with special responsibilities for supervision of the biomedical cores. The Center's administrative team will be assisted by an Executive Committee, an Internal Advisory Committee, and two External Scientific Advisors, Drs. Michael Brenner and Michael Holers. The UM-RDCC is constructed to maximally engage the talents and resources of the University of Michigan to focus on research in the rheumatic diseases. The Center leadership will maintain close links between the basic and pre-clinical research activities of the UM-RDCC and expanding clinical investigation in the rheumatic diseases at the University of Michigan, so as to maximize the impact of UM-RDCC discoveries on the health of patients with rheumatic diseases.

密歇根大学提议为其风湿病研究核心中心(UM-RDCC)重新提供资金。UM-RDCC是一项基础广泛的工作，涉及大约80名教员，他们寻求应用广泛的研究技能、背景和方法来调查风湿病的病因和发病机制中的基本问题，并为新的治疗方法开发科学基础。UM-RDCC将促进研究人员在研究实力和兴趣的主题领域的合作，如创新疗法的开发和测试、风湿病免疫机制的分析以及器官靶向炎症和组织重塑途径的调查。UM-RDCC还将促进与临床研究计划相关的以疾病为重点的实验室和转化性研究。该中心的活动将得到六个生物医学核心设施的支持，包括流式细胞术、杂交瘤、载体、转基因动物、蛋白质结构和微阵列。提出了三个试点和可行性项目，其中两个是由UMRDCC最近招聘的新教师领导的，其重点是炎性关节炎的发病机制。第三个试点和可行性项目由一位经验丰富的皮肤病调查员领导，他将机械地研究一种治疗硬皮病的高度创新的方法。UM-RDCC及其行政单位将由David A.Fox医学博士领导，他在管理基础广泛的NIAMS资助的中心项目方面拥有15年的经验。风湿病学副教授，医学博士Rory Marks建议继续担任UMRDCC副主任，专门负责监督生物医学核心。该中心的管理团队将由一个执行委员会、一个内部咨询委员会以及两名外部科学顾问Michael Brenner博士和Michael Holers博士提供协助。UM-RDCC的构建是为了最大限度地利用密歇根大学的人才和资源，专注于风湿病的研究。中心领导层将在UM-RDCC的基础和临床前研究活动与密歇根大学扩大风湿病临床研究之间保持密切联系，以最大限度地提高UM-RDCC发现对风湿病患者健康的影响。

项目成果

MHC molecules in health and disease: At the cusp of a paradigm shift.

健康和疾病中的 MHC 分子：处于范式转变的风口浪尖。

• DOI: 10.4161/self.2.1.15757
• 发表时间: 2011
• 期刊: Self/nonself
• 作者: deAlmeida,DeniseE;Holoshitz,Joseph
• 通讯作者: Holoshitz,Joseph

Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance.

• DOI: 10.1016/j.stem.2008.10.005
• 发表时间: 2009-02-06
• 期刊: Cell stem cell
• 影响因子: 23.9
• 作者: Kiel MJ;Acar M;Radice GL;Morrison SJ
• 通讯作者: Morrison SJ

Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes.

• DOI: 10.1016/j.joca.2010.09.006
• 发表时间: 2010-12
• 期刊: OSTEOARTHRITIS AND CARTILAGE
• 影响因子: 7
• 作者: Ohba, S.;Lanigan, T. M.;Roessler, B. J.
• 通讯作者: Roessler, B. J.

A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs.

• DOI: 10.4049/jimmunol.0902199
• 发表时间: 2010-03-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Denny MF;Yalavarthi S;Zhao W;Thacker SG;Anderson M;Sandy AR;McCune WJ;Kaplan MJ
• 通讯作者: Kaplan MJ

Type I interferons are associated with subclinical markers of cardiovascular disease in a cohort of systemic lupus erythematosus patients.

• DOI: 10.1371/journal.pone.0037000
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Somers EC;Zhao W;Lewis EE;Wang L;Wing JJ;Sundaram B;Kazerooni EA;McCune WJ;Kaplan MJ
• 通讯作者: Kaplan MJ