University of Michigan Rheumatic Diseases Core Center

密歇根大学提议建立风湿病核心中心。这将是一项基础广泛的努力，涉及密歇根大学临床和基础科学系及其邻近机构的约80名教职员工。该中心将应用广泛的研究技能、背景和方法来调查风湿病的病因和发病机制中的基本问题，并开发新疗法的科学基础。该中心将通过将研究人员集中在四个主要项目(器官炎症和损伤中的创新治疗、自身免疫、细胞和细胞因子相互作用的模型系统，以及风湿性疾病中的遗传学和基因表达模式)以及以疾病为重点的工作组(骨性关节炎、牛皮癣/牛皮癣关节炎、类风湿性关节炎和系统性红斑狼疮)来集中其活动。该中心的活动将得到六个生物医学核心设施的支持，包括流式细胞术、杂交瘤、载体、转基因动物、蛋白质结构和DNA测序核心。UM-RDCC教职员工将以大幅折扣的充值率获得风湿病相关研究的核心服务。提出了两个试点项目和可行性项目，每个项目都由密歇根大学最近招聘的新教师领导。UM-RDCC及其行政单位将由David A.Fox医学博士领导，他在管理一个基础广泛的中心方面有十多年的经验，领导密歇根大学多功能关节炎和肌肉骨骼疾病中心。风湿病学副教授，医学博士Rory Marks被提议担任UM-RDCC副主任，专门负责监督生物医学核心。该中心的领导层将在密歇根大学的基础研究活动和扩大风湿性疾病的临床研究之间保持密切联系。该中心的管理团队将由执行委员会、内部咨询委员会和外部科学顾问本尼斯·卡森博士提供协助。我们建立了UM-RDCC，以最大限度地利用密歇根大学的人才和资源，专注于风湿病在风湿病中的基础研究，从而在提高对病因、发病机制和治疗的认识方面取得实质性进展。

The University of Michigan proposes to establish a Rheumatic Disease Core Center. This will be a broadly based effort involving approximately 80 faculty from clinical and basic science departments at the University of Michigan and neighboring institutions. The Center will apply a broad range of research skills, backgrounds, and approaches to investigation of fundamental issues in the etiology and pathogenesis of rheumatic diseases and in development of a scientific basis for novel therapeutics. The Center will focus its activities by grouping investigators in four Major Programs (Model Systems for Innovative Therapeutics, Autoimmunity, Cell and Cytokine Interactions in Organ Inflammation and Damage, and Genetics and Patterns of Gene Expression in the Rheumatic Diseases); and also in Disease Focused Working Groups (Osteoarthritis, Psoriasis/Psoriatic Arthritis, Rheumatoid Arthritis and Systemic Lupus Erythematosis). Activities of the Center will be supported by six Biomedical Core Facilities including Flow Cytometry, Hybridoma, Vector, Transgenic Animal, Protein Structure and DNA Sequencing Cores. UM-RDCC faculty will have access to core services for rheumatic disease-related research at substantially discounted recharge rates. Two Pilot and Feasibility Projected are proposed, each of which is led by new faculty recently recruited to the University of Michigan. The UM-RDCC and its administrative unit will be directed by David A. Fox, M.D., who is experienced in administration of a broadly based Center through more than ten years directing the University of Michigan Multipurpose Arthritis and Musculoskeletal Diseases Center. Rory Marks, M.D., Associate Professor of Rheumatology is proposed as the UM-RDCC Associate Director, with special responsibilities for supervision of the biomedical cores. The Center leadership will maintain close links between the basic research activities of the UM-RDCC and expanding clinical investigation in the rheumatic diseases at the University of Michigan. The Center's administrative team will be assisted by an Executive Committee, an Internal Advisory Committee, and an External Scientific Advisor, Dr. Bennis Carson. We have constructed the UM- RDCC to maximally engage the talents and resources of the University of Michigan to focus on basic research in the rheumatic diseases in the rheumatic diseases, so as to achieve substantial progress in improving understanding of etiology, pathogenesis and treatment.