GROWTH CONE ACTIVITY AND NEURONAL PLASTICITY

生长锥活性和神经元可塑性

• 批准号: 6437408
• 负责人: CHUN-FANG WU
• 金额: $ 14.32万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2002-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6437408
• 关键词: Drosophilidae; cell adhesion; cell adhesion molecules; cell biology; cell growth regulation; cell motility; cyclic AMP; cytoskeleton; enzyme activity; growth cones; membrane activity; membrane proteins; mutant; neural plasticity; neurogenesis; neurogenetics; neuromuscular junction; neurons; neurophysiology; potassium channel; protein kinase C; protein structure function; second messengers; sodium channel; tissue /cell culture

This proposal seeks to characterize the cellular mechanisms underlying neuronal development and plasticity in Drosophila. It investigates the roles of second messenger systems, membrane excitability, membrane cycling, and cell adhesion, using methods of genetics, physiology, and cell biology. The proposal addresses a wide variety of issues relating to neuronal development and plasticity. It contains 9 specific aims, and the principal issues addressed are: 1) the role of second messenger systems in organizing the neuronal cytoskeleton and in the physiology of the neuromuscular junction; 2) the influence of nerve excitability and activity on cytoskeletal organization in cultured neurons and flight muscles; 3) the role of membrane vesicle proteins in regulating the addition of new membranes in neuronal development (e.g. as reflected in growth cone formation and neurite growth rates); 4) the role of the cytoplasmic tyrosine kinase abl and related proteins in cytoskeletal organization and neuronal adhesion.

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