Self-assembly of Nanoscopic Analogues of Lipoproteins

脂蛋白纳米类似物的自组装

• 批准号: 6551644
• 负责人: JUAN NOVERON
• 金额: $ 4.42万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6551644
• 关键词: analog; apolipoproteins; atomic force microscopy; biological transport; chromatography; drug vehicle; mass spectrometry; nanotechnology; nuclear magnetic resonance spectroscopy; postdoctoral investigator; scanning tunneling microscopy; synthetic protein; transmission electron microscopy; transport proteins

DESCRIPTION (provided by applicant): Synthetic nanoscopic materials that are able to mimic the structure and functional aspects of biological transport systems such as lipoproteins and viruses are promising as targetable transport systems for low molecular weight drugs, recombinant proteins, and genes. In recent years, metal-directed self-assembly has been the subject of explosive development making possible the synthesis of discrete rianostructures with sizes and molecular weights comparable to proteins. This proposal is concerned with the synthesis of rationally designed molecular units programmed to self-assemble via dative coordination bonds into discrete polyhedral nanostructures. These ensembles will contain pendant amino acids or lipid groups that, upon self-organization of the molecular units, can cluster together to model the structure and transport function properties of lipoproteins. The long-term objective of this research is the development of these self-assembled polyhedral nanostructures into lipoprotein-like transport systems that may serve as new drug delivery vehicles of hydrophobic medicines. Our research design will also pave the way for the preparation of synthetic supramolecular assemblies that model the internal molecular environment of metallo-enzymes and from which new practical bioinspired catalytic systems may spawn.

描述（由申请人提供）：能够模拟生物转运系统（例如脂蛋白和病毒）的结构和功能方面的合成纳米材料有望作为低分子量药物、重组蛋白和基因的靶向转运系统。近年来，金属定向自组装已成为爆炸性发展的主题，使得合成尺寸和分子量与蛋白质相当的离散纤维结构成为可能。该提案涉及合理设计的分子单元的合成，这些分子单元被编程为通过配位配位键自组装成离散的多面体纳米结构。这些集合体将包含侧链氨基酸或脂质基团，在分子单元的自组织后，它们可以聚集在一起以模拟脂蛋白的结构和转运功能特性。这项研究的长期目标是将这些自组装多面体纳米结构开发成脂蛋白样运输系统，该系统可以作为疏水性药物的新药物递送载体。我们的研究设计还将为合成超分子组装体的制备铺平道路，该组装体可以模拟金属酶的内部分子环境，并从中产生新的实用仿生催化系统。