Web-based Training & Reliability for Psychiatric Trials

基于网络的培训

• 批准号: 6443509
• 负责人: DEBRA L FOX
• 金额: $ 9.97万
• 依托单位: FOX LEARNING SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443509
• 关键词: Internet; bias; clinical trials; computer assisted instruction; computer program /software; computer system design /evaluation; diagnosis quality /standard; human subject; interactive multimedia; interview; mental disorder diagnosis; psychiatry; psychometrics

DESCRIPTION (provided by applicant) The important task of training raters and establishing and maintaining reliability for the duration of a psychiatric clinical trial is a major problem that is often ignored. This problem is particularly vexing for trials involving many raters at multiple sites. Furthermore, factors effecting rater expectancy (bias) with standard psychiatric rating instruments has never been fully explored. This proposal will develop an interactive video system that can train research raters to use rating instruments with shared rating conventions and assess interrater reliability across sites and over time. Programs will be written that will enable this video system to be used as (I) an interactive "tutorial" system that can provide immediate feedback to trainees, and (2) a "reliability testing" system, that uses an integrated database to record ratings and compute interrater reliability within an identified group of raters or with preset ratings ("a gold standard"). Phase I will create a prototype for assessing interrater reliability for the Hamilton Depression Rating Scale (HDRS). Using scripts from actual patient interviews, a male and a female actor will each portray three separate HDRS interviews reflecting depressive symptoms of various severity. The functionality of the prototype system will be assessed. In preparation for Phase II, feasibility will be established by 1) having experienced raters assess videos of the HDRS interviews of both actors and actual patients to establish the validity of the actors' portrayals. 2) assessing interrater reliability in a group of experienced raters and a group of novice raters using the system, and 3) assessing the positive and negative attributes of the system with both experienced and novice raters. Phase II will develop a complete library of 30 variations of the I-IDRS using 6 different actors of diverse age, gender and ethnicity and implement the tutorial system. The Phase II study will assess variability and rater bias as an interaction of demographic and professional characteristics of the raters and "patients." Future product development will utilize the software and statistical methodology with other rating instruments, including those used to assess schizophrenia, anxiety disorders, and dementia. PROPOSED COMMERCIAL APPLICATION: The primary market for this product consists of any large organization involved in the conduct of psychiatric clinical trials, including academic medical centers, pharmaceutical companies, and contract research organizations. Another potential market is the managed care companies that use a growing number of rating scales to assess outcomes and quality of psychiatric and behavioral health services across multiple clinical sites.

描述（由申请人提供）培训评分员的重要任务， 在精神病治疗期间建立和保持可靠性 临床试验是一个经常被忽视的主要问题。这个问题 对于涉及多个地点的许多评分者的试验来说尤其令人烦恼。 此外，影响评分员期望（偏差）的因素与标准 精神病评估工具从未被充分开发。这项建议 将开发一个交互式视频系统，可以训练研究评级员使用 具有共同评级惯例的评级工具，并评估评级者之间的关系 跨站点和跨时间的可靠性。程序将被编写， 使这个视频系统能够用作（I）交互式“教程”系统 可以为学员提供即时反馈，以及（2）“可靠性 测试”系统，它使用一个集成的数据库来记录评级和计算 确定的一组评分者或预设的评分者间可靠性 评级（“黄金标准”）。第一阶段将建立一个原型， 汉密尔顿抑郁评定量表（HDRS）的评定者间信度。使用 从实际的病人访谈脚本，一男一女演员将分别 描绘了三个独立的HDRS访谈，反映了抑郁症状， 各种严重性。将评估原型系统的功能。 在第二阶段的准备工作中，将通过1） 经验丰富的评分员评估了演员和 真实的病人来确定演员的真实性。（二） 在一组有经验的评分者和一组 的新手评分员使用该系统，和3）评估的积极和消极的 系统的属性与经验丰富的和新手评分员。二期将 开发一个完整的库的30个变化的I-IDRS使用6个不同的 该委员会鼓励不同年龄、性别和民族的演员参加，并实行导师制。 II期研究将评估变异性和评估者偏倚，作为以下因素的相互作用： 评估者和“患者”的人口统计学和专业特征。" 未来的产品开发将利用软件和统计 其他评级工具，包括用于评估 精神分裂症焦虑症和痴呆症 拟定商业应用：该产品的主要市场包括参与精神病临床试验的任何大型组织，包括学术医疗中心，制药公司和合同研究组织。另一个潜在的市场是管理式护理公司，这些公司使用越来越多的评级量表来评估多个临床站点的精神和行为健康服务的结果和质量。