Effects of LSVT on Dysphagia in Parkinson's Disease

LSVT 对帕金森病吞咽困难的影响

• 批准号: 6479812
• 负责人: JERILYN A LOGEMANN
• 金额: $ 13.69万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6479812
• 关键词: Parkinson's disease; clinical research; dysphagia; gastrointestinal imaging /visualization; gastrointestinal motility /pressure; gastrointestinal sign /symptom; human subject; human therapy evaluation; patient oriented research; speech therapy; swallowing

DESCRIPTION (provided by applicant): Lee Silverman Voice Treatment (LSVT) has shown promise in improving swallow, as well as voice and speech. This project is designed to define the effects of LSVT on swallow in patients who exhibit VFG verified aspiration on any food volume or viscosity. Thirty patients with idiopathic Parkinson's disease, who aspirate (with or without cough response) on any food consistency, will serve as subjects in this study. When identified clinically as at-risk for aspiration, patients will receive a modified barium swallow on a standard protocol, followed by randomization to immediate LSVT treatment for 1-month (4 sessions per-week for 4-weeks) or delayed LSVT beginning 1-month after the first group's therapy is completed. Thus, the comparison of critical interest is therapy vs. no therapy. The delayed group will serve as the no therapy arm. Patients in both arms will receive instructions on diet and posture modification, as necessary, based on the results of VFG. Patients will receive no other swallowing therapy or voice or speech therapy during this 2-month period when both groups receive treatment. After completion of one-month of therapy, patients will receive a modified barium swallow assessment to document change. Medication schedules will remain unchanged throughout the study, and patients will receive their modified barium swallow studies at the same time of day relative to medication both pre- and post-LSVT treatment. The outcome measure will be the elimination of aspiration. We will also define, as secondary measures, the changes in bolus transit times, the observation of percentage residue in the mouth and pharynx, the frequency of swallowing motility disorders and the temporal measures of swallow. These will all serve as explanatory variables for changes in frequency of occurrence of aspiration. This application proposes to generate pilot data on the effects of LSVT on aspiration, a potentially dangerous and costly side effect of dysphagia in Parkinson's disease.

描述(申请人提供)：Lee Silverman语音治疗(LSVT) 在改善吞咽能力、声音和语言能力方面表现出了希望。这个项目 旨在确定LSVT对以下患者吞咽的影响 VFG验证了对任何食物体积或粘度的吸入。30名患者患有 特发性帕金森病，吸气(伴有或不伴有咳嗽反应) 关于任何食物的稠度，都将作为本研究的对象。当被识别时 临床上，由于有误吸的危险，患者将接受改良的X线检查。 接受标准方案，然后随机化立即进行LSVT 治疗1个月(每周4次，为期4周)或延迟LSVT 自第一组治疗结束后1个月开始。因此， 关键利益的比较是治疗与不治疗。延迟组 将作为不接受治疗的手臂。双臂的患者将会收到 关于饮食和姿势调整的说明，如有必要，请根据 VFG检查结果。患者将不会接受其他吞咽治疗或发声或 在这两组都接受治疗的2个月期间进行语言治疗。 在完成一个月的治疗后，患者将接受改良的 吞钡评估对文件的更改。用药时间表将保持不变 在整个研究过程中没有变化，患者将接受他们的改良剂 与服药前和服药前相比，每天同一时间的吞咽研究 LSVT治疗后。结果的衡量标准将是消除抱负。 我们还将把推注转运时间的变化定义为次要措施， 口腔、咽部残留率、残留频率的观察 吞咽运动障碍和吞咽的时间测量。这些 都将作为发生频率变化的解释变量 渴望的力量。这个应用程序建议生成有关效果的试点数据 LSVT对吸入的潜在危险和代价高昂的副作用 帕金森氏症的吞咽困难。