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ELABORATION OF MODIFIED PROTEINS USING MISACYLATED TRNAS

ELABORATION OF MODIFIED PROTEINS USING MISACYLATED TRNAS
使用异酰化 TRNAS 精制修饰蛋白
批准号:
6556208
负责人:
Sidney Michael Hecht
金额:
$3.08万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-04-01 至 2003-03-31

项目摘要

项目成果

Sidney Michael Hecht的其他基金

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中文摘要
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英文摘要
DESCRIPTION: The long-term goal is the elaboration and study of proteins containing synthetic amino acids at specific, predetermined positions and the kinetics of there enzyme reactions These are to be incorporated by read throug of nonsense codons with misacylated suppressor tRNAs. It is proposed to continue the preparation and study of analogs of E. coli dihydrofolate reductase, firefly luciferase and HIV-1 protease. Also proposed for study are methods that have the potential to increase the efficiency of synthesis of the analogs of interest, as well as the repertoire of amino acid analogs that can be incorporated.
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NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE
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  • 项目类别:
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  • 财政年份:
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    6772479
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NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE
  • 批准号:
    6662525
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  • 负责人:
    Sidney Michael Hecht
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NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE
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    6375851
  • 项目类别:
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  • 财政年份:
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