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NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE

NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE
天然产品的发现 - 核和信号目标
批准号:
6772479
负责人:
Sidney Michael Hecht
金额:
$96.99万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-09-30 至 2006-05-31

项目摘要

项目成果

Sidney Michael Hecht的其他基金

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中文摘要
翻译
描述:(申请人描述)
英文摘要
DESCRIPTION: (Applicant's Description) The long term objective of this NCNPDDG is the identification of compounds suitable for development as antitumor agents. This is to be done by 1. utilizing existing, validated assay to guide the screening/isolation of novel DNA damaging agents, and inhibitors of DNA topoisomerase I, DNA topoisomerase II, DNA polymerase B and Myt1 kinase (Programs 1, 2 and 3) 2. developing new mechanism-based assays as high-throughput primary screens for natural products with potential activity in the treatment of cancer, including inhibitors of proliferation-linked signal transduction (Program 1) 3. fractionating lead extracts and characterizing isolated natural products derived from each of the assay systems as chemical entities and biological mediators (Programs 2 and 3) 4. developing and utilizing secondary discriminators to guide the focused identification of natural/products/structurally modified compounds predicted to have useful antitumor activity (Programs 1 and 3) 5. preparing in quantity and evaluating promising compounds in tumor cells (for mechanism, biochemical pharmacology, interaction with known antineoplastic agents) and in animal tumor models (Programs 1-3)
期刊论文(14)
专著(0)
科研奖励(0)
会议论文
Bioactive compounds from Combretum erythrophyllum.
来自红叶风车草的生物活性化合物。
DOI: 10.1021/np9904410
发表时间: 2000
期刊: Journal of natural products
影响因子: 5.1
作者: [Schwikkard,S, Zhou,BN, Glass,TE, Sharp,JL, Mattern,MR, Johnson,RK, Kingston,DG]
通讯作者: Kingston,DG
DOI: 10.1021/np000058r
发表时间: 2000-07
期刊: Journal of natural products
影响因子: 5.1
作者: [Bing-Nan Zhou;Jeannine M. Hoch;Randall K. Johnson;Michael R. Mattern;Wai-Kwong Eng;Ji Ma;Sidney M. H]
通讯作者: Bing-Nan Zhou;Jeannine M. Hoch;Randall K. Johnson;Michael R. Mattern;Wai-Kwong Eng;Ji Ma;Sidney M. H
DOI: 10.1021/np990442s
发表时间: 2000-01
期刊: Journal of natural products
影响因子: 5.1
作者: [Bing-Nan Zhou;Randall K. Johnson;Michael R. Mattern;Xiangyang Wang;Sidney M. Hecht;Hans T. Beck;A. Ortiz;David G. I. Kingston]
通讯作者: Bing-Nan Zhou;Randall K. Johnson;Michael R. Mattern;Xiangyang Wang;Sidney M. Hecht;Hans T. Beck;A. Ortiz;David G. I. Kingston
DOI: 10.1016/j.bmc.2004.11.039
发表时间: 2005-02-15
期刊: BIOORGANIC & MEDICINAL CHEMISTRY
影响因子: 3.5
作者: [Cao, SG, Foster, C, Kingston, DGI]
通讯作者: Kingston, DGI
6
    NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE
    • 批准号:
      6166332
    • 项目类别:
    • 资助金额:
      $53.32万
    • 财政年份:
      2000
    • 负责人:
      Sidney Michael Hecht
    • 依托单位:
    NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE
    • 批准号:
      6662525
    • 项目类别:
    • 资助金额:
      $92.77万
    • 财政年份:
      2000
    • 负责人:
      Sidney Michael Hecht
    • 依托单位:
    NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE
    • 批准号:
      6375851
    • 项目类别:
    • 资助金额:
      $87.63万
    • 财政年份:
      2000
    • 负责人:
      Sidney Michael Hecht
    • 依托单位:
    NATURAL PRODUCTS DISCOVERY - NUCLEAR AND SIGNALING TARGE
    • 批准号:
      6512660
    • 项目类别:
    • 资助金额:
      $91.63万
    • 财政年份:
      2000
    • 负责人:
      Sidney Michael Hecht
    • 依托单位:
    海外基金