Controlled polymer architectures for the delivery of polynucleotides

用于递送多核苷酸的受控聚合物结构

• 批准号: 1938888
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1938888
• 关键词: Controlled; polymer; architectures; delivery; polynucleotides

The project focuses on the design of polyelectrolytes of controlled architectures to complex a variety of polynucleotides and control their delivery into cells, with a particular focus on the treatment of cancer. A range of polymeric architectures will be studied including linear and branched copolymers, which will be functionalised to target delivery and also carry probe molecules allowing tagging of the delivery vectors for in situ imaging.

该项目的重点是设计受控结构的聚电解质，使各种多核苷酸复杂化，并控制它们进入细胞的输送，特别是癌症的治疗。将研究一系列聚合物结构，包括线形和支化共聚物，它们将被功能化以进行靶向传递，并携带允许标记传递载体以进行原位成像的探针分子。

项目成果

PCR-RAFT: rapid high throughput oxygen tolerant RAFT polymer synthesis in a biology laboratory

• DOI: 10.1039/c9py01521c
• 发表时间: 2020-02-14
• 期刊: POLYMER CHEMISTRY
• 影响因子: 4.6
• 作者: Gurnani, Pratik;Floyd, Thomas;Perrier, Sebastien
• 通讯作者: Perrier, Sebastien