CONCENTRATED AEROSOL DELIVERY AND QUANTIZATION SYSTEM

浓缩气溶胶输送和量化系统

• 批准号: 6527188
• 负责人: Donovan B Yeates
• 金额: $ 34.8万
• 依托单位: BIOTECHPLEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6527188
• 关键词: aerosols; biomedical equipment development; drug delivery systems; fluoresceins; inhalation drug administration; laboratory rat; measurement; physical property; plethysmography; spectrometry

DESCRIPTION (provided by applicant): BioTechPlex Corporation proposes to develop an improved aerosol delivery system. The proposed system, Concentrated Aerosol Delivery and Quantization System, CADAQS, will fulfill the need to acutely deliver high particle number concentrations of aerosols to the respiratory tract of small animals (rats, young rabbits, and guinea pigs: wt < 1000 g), while enabling the quantization of their deposition in the lungs. The CADAQS consists of 3 subsystems. A) A two stage aerosol concentrator, TSAC, concentrates aerosols of 1-5 pm AMMD. B) A Small Animal Aerosol Delivery System, SAADS, a zero-dead space nose cone incorporated into a whole body plethysmograph complete with sensors and data acquisition and analysis system. C) A Quantitative Aerosol Deposition System, QADS, utilizes a pair of 4 pixelated CdZnTi detectors with integrated ASIC placed laterally to each lung. In Phase I, we successfully constructed the TSAC prototype. In this Phase II project, we will construct the complete CADQAS system so that prototypes of commercial systems can be generated. The system will be tested using rats. The TSAC, the SAADS, and the QADS are designed to be sold as stand-alone devices as well as components of CADAQS. Such a system is not available commercially. This system will be used for environmental and occupational toxicology. It will also greatly facilitate the processes of drug discovery, toxicology and pharmacology through the delivery of drugs to the respiratory tract for both local and systemic drug delivery. PROPOSED COMMERCIAL APPLICATION: This system is designed to deliver concentrated aerosols to small animals while enabling the quantization of aerosols deposited in the lungs. This system can also act as a forerunner of the development of technologies for measuring cardiopulmonary function and aerosol delivery to premature infants.

描述（由申请人提供）：BioTech Corporation建议 开发一种改进的气溶胶输送系统。建议的系统，集中 气溶胶输送和量化系统，CADAQ，将满足需要， 将高颗粒数浓度的气溶胶急剧输送到 小动物（大鼠、幼兔和豚鼠：wt < 1000 g），同时能够量化它们在肺部的沉积。的 CADAQ由三个子系统组成。A）两级气溶胶浓缩器TSAC， 浓缩1-5 pm AMMD的气溶胶。B）小动物气溶胶递送 系统，SAADS，一个零死区空间鼻锥， 体积描记器配有传感器和数据采集和分析系统。 C）定量气溶胶沉积系统，QADS，利用一对4 集成ASIC的像素化CdZnTi探测器横向放置在每个肺部。 在第一阶段，我们成功地建造了TSAC原型。在此第二阶段 项目，我们将构建完整的CADQAS系统，使原型的 可以建立商业系统。该系统将使用大鼠进行测试。的 TSAC、SAADS和QADS设计为作为独立设备销售， 也是CADAQ的组成部分。这样的系统在商业上是不可得的。这 系统将用于环境和职业毒理学。它还将 极大地促进了药物发现、毒理学和药理学的过程， 通过将药物输送到呼吸道， 全身给药。 拟定商业应用： 该系统旨在将浓缩的气溶胶输送给小动物，同时能够量化沉积在肺部的气溶胶。该系统还可以作为测量早产儿心肺功能和气雾剂输送技术发展的先驱。