INHALED ENVIRONMENTAL/OCCUPATIONAL IRRITANTS/ALLERGENS

吸入环境/职业刺激物/过敏原

• 批准号: 6483306
• 负责人: Donovan B Yeates
• 金额: $ 2.7万
• 依托单位: AMERICAN THORACIC SOCIETY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-20 至 2001-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6483306
• 关键词: airborne allergen; cardiopulmonary disease; environmental exposure; irritation /irritant; occupational disease /disorder; travel; workshop

Epidemiological data demonstrate increases in daily morbidity and mortality associated with short-term increases in levels of particles and associated pollutants. The primary causes of death appear to be respiratory and cardiovascular incidents in persons with compromised cardiopulmonary function, with asthmatics among the higher risk groups. The mechanisms whereby the inhaled pollutants lead to the observed responses are a matter considerable current scientific speculation and regulatory concern. This three-day workshop to be held March 30 - April 2, 2000, focuses on the acute pulmonary, cardiac, vascular and systemic responses to the inhalation of environmental and occupational and indoor airborne particles and co-pollutants that give rise to compromised physiologic function that may lead to the observed increases in morbidity and mortality. Because biological amplifiers evoked by allergens and irritants share some common pathways, the inter-comparison of the mechanisms activated or modified by these two groups of agents is intended to be emphasized in the conference. At this workshop, scientists with divergent interests related to the potential cardiopulmonary and systemic sequelae of inhaled agents will bring new insight into the potential mechanisms whereby inhaled irritants and allergens may elicit the observed responses. 1. A three-day workshop will be conducted to bring scientific experts from different disciplines together to share information on the acute mechanisms potentially involved in the debilitating and life-threatening sequelae of the inhalation of allergens, particles, and co-pollutants, to form hypotheses from the newly- shared diverse information, and to reach consensus on critical current research needs. 2. On the third day, the participants will formulate and consensus statements on current knowledge and prioritize new research needs and directions. This will be developed by the discussion group leaders into a written synthesis of current knowledge and recommendations. 3. The results of the workshop will be published in two formats. The proceedings in the form of papers resulting from presentations will be peer-reviewed and published in the journal Environmental Health Perspectives. The synthesis of current knowledge and research recommendations will be published in the American Journal of Respiratory and Critical Care Medicine.

流行病学数据表明，每日发病率和死亡率的增加与颗粒物和相关污染物水平的短期增加有关。死亡的主要原因似乎是心肺功能受损者的呼吸和心血管事件，其中哮喘患者属于高危人群。吸入污染物导致观察到的反应的机制是当前科学推测和监管关注的一个重要问题。这个为期三天的研讨会将于2000年3月30日至4月2日举行，重点讨论吸入环境、职业和室内空气颗粒和共污染物对肺部、心脏、血管和全身的急性反应，这些反应会导致生理功能受损，从而可能导致发病率和死亡率增加。由于过敏原和刺激物引起的生物放大器具有一些共同的途径，因此会议旨在强调这两组药物激活或改变的机制的相互比较。在本次研讨会上，对吸入剂潜在心肺和全身后遗症具有不同兴趣的科学家将对吸入刺激物和过敏原可能引起观察到的反应的潜在机制提出新的见解。 1. 将举办为期三天的研讨会，将来自不同学科的科学专家聚集在一起，分享有关吸入过敏原、颗粒和共污染物导致衰弱和危及生命的后遗症的急性机制的信息，根据新分享的各种信息形成假设，并就当前的关键研究需求达成共识。 2. 第三天，参与者将就当前知识制定共识声明，并优先考虑新的研究需求和方向。讨论小组领导者将把该文件发展成当前知识和建议的书面综合。 3. 研讨会成果将以两种形式发布。会议记录以论文形式发表，将接受同行评审并发表在《环境健康展望》杂志上。当前知识和研究建议的综合将发表在《美国呼吸与重症监护医学杂志》上。