NOVEL PUMP FOR TIDAL FLOW EXTRACORPOREAL SUPPORT

用于潮汐流体外支持的新型泵

• 批准号: 6530705
• 负责人: Scott I Merz
• 金额: $ 36.32万
• 依托单位: MC3, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-20 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6530705
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; catheterization; circulatory assist; computer program /software; computer system design /evaluation; dialysis therapy; extracorporeal circulation; hemodialysis

DESCRIPTION (Unedited Applicant's Abstract):Extracorporeal Circulation is used in several blood treatment applications, including hemodialysis, respiratory support, and blood warming/cooling. These procedures usually require two vascular access sites; one for draining blood and the other returning treated blood. The blood treatment applications can also be performed using a single cannula in a tidal flow arrangement that alternately drains and infuses a volume of blood. The use of a single cannula system has considerable cost and safety advantages over the current two-cannula system. The Baxter MetaPlus Pump possesses safety features that make it the only commercially available pump suitable for use in a single cannula, tidal flow configuration. A tidal flow extracorporeal blood pump (T-Pump) will be developed in the form of an auxiliary electronic controller and clamp assembly designed to be used in conjunction with the MetaPlus pump. A novel clamp configuration and flow control algorithm will be employed to increase safety and efficacy, and allow the system to adapt to changes in patient blood flow/pressure conditions. Phase II research will include refinement of control software, design of a control console, modification of clamp design, extensive evaluation in vivo, and packaging of the system. PROPOSED COMMERCIAL APPLICATION: Not Available

说明(未经编辑的申请人摘要)：使用体外循环 在几种血液治疗应用中，包括血液透析、呼吸 支持，以及血液变暖/降温。这些程序通常需要两个 血管通路；一个用于引流血液，另一个用于返回治疗 血。血液处理应用程序也可以使用单个 潮汐流动装置中的插管，交替地排出和注入 出血量。使用单一的插管系统具有相当大的成本和 与目前的两套套管系统相比，具有安全优势。Baxter MetaPlus泵 具有安全功能，使其成为唯一可用于商业用途的泵 适用于单插管、潮汐流量配置。潮水般的水流 体外血泵(T泵)将以一种 辅助电子控制器和夹具组件设计用于 与MetaPlus泵配合使用。一种新型的夹具结构和流量 将采用控制算法来提高安全性和有效性，并允许 该系统能够适应患者血流/压力条件的变化。阶段 Ii研究将包括改进控制软件、设计控制 控制台，夹具设计的改进，在体内的广泛评估，以及 系统的包装。 建议的商业应用： 不可用