Enhanced Nitric Oxide-Releasing Materials

描述（由申请人提供）：本研究的目的是将一氧化氮（NO）释放化合物掺入聚合物制剂中，用于改善血管内和体外器械血液接触表面的生物相容性。先前的研究已经证明，用连续释放少量NO的聚合物层涂覆表面抑制血小板活化和粘附。早期的材料限制了实际应用，因为它们不足以稳定以承受制造和储存，并且因为低NO容量需要非常厚的涂层。已经开发了新的NO捐助者来解决这些问题。这些材料具有显著更高的NO容量;因此可以用更薄的涂层输送更多的NO。这些材料的保质期也比其前身更长。两种NO供体将用于形成聚合物涂层，该涂层可应用于套管、导管和体外血液处理装置中常用的材料。将设计配方以提供足够的NO剂量和尽可能少的涂层材料。将测试材料承受制造、灭菌和储存中典型条件的能力。将采用动物模型评价生物相容性和材料防止血小板活化和粘附的能力。

DESCRIPTION (provided by applicant): The goal of this study is to incorporate nitric oxide (NO)-releasing compounds into polymer formulations that can be used to improve the biocompatibility of blood-contact surfaces in intravascular and extracorporeal devices. Previous studies have demonstrated that coating surfaces with polymer layers that continuously released small amounts of NO inhibited platelet activation and adhesion. Earlier materials had limited practical applications because they were not sufficiently stable to withstand manufacturing and storage, and because low NO capacity required prohibitively thick coatings. New NO donors have been developed that address these issues. The materials have significantly higher NO capacities; so more NO can be delivered with thinner coatings. These materials also have longer shelf life than their predecessors. Two NO donors will be used to form polymer coatings that can be applied to materials commonly used in cannulas, catheters, and extracorporeal blood treatment devices. Formulations will be devised to provide sufficient NO dose with the minimum possible coating material. The materials will be tested for their ability to withstand conditions typical in manufacturing, sterilization and storage. An animal model will be employed to evaluate biocompatibility and the ability of the materials to prevent platelet activation and adhesion.