CHEMOSENSORY CLINICAL RESEARCH CENTER

莫奈尔·杰斐逊化学感觉临床研究中心（CCRC）是由莫奈尔化学感觉中心的科学家和托马斯·杰斐逊大学的医生合作建立的。与宾夕法尼亚大学和费城退伍军人事务医学中心的医生和科学家也有合作项目。CCRC致力于味觉、嗅觉和化学刺激的临床疾病的科学检查，以及人类化学感官的基础研究。通过对临床人群的多学科研究，CCRC科学家希望能够描述和了解化学感觉功能障碍的病因，提供有关人类化学感觉机制和功能的信息，并制定治疗/应对化学感觉障碍的策略。CCRC的更新将包括一个行政核心单位，一个感觉核心单位（监督对化学感觉障碍的原诉转诊患者的评估，并将患者转诊到特定项目）和三个单独的研究项目。CCRC的总体目标是：1)继续为化学感觉障碍的评估及其病因和预后研究提供临床设施，特别强调对患者的随访和评估化学感觉障碍患者的生活质量；2)继续在细胞水平上研究人类嗅觉功能，将敏感的电生理和生物物理技术应用于从健康的年轻人和老年人以及神经退行性疾病患者收集的人体活检材料；3)增加我们对患者和非患者群体嗅觉适应和恢复动态过程中受体周围事件作用的认识；4)以嗅觉缺失患者和嗅觉正常患者为实验对象，继续揭示鼻内化学合成与嗅觉之间的关系。

The Monell Jefferson Chemosensory Clinical Research Center (CCRC) involves a collaboration between scientists at the Monell Chemical Senses Center and physicians at Thomas Jefferson University. Collaborative projects also exist with physicians and scientists at the University of Pennsylvania and the Veterans Affairs Medical Center of Philadelphia. The CCRC is devoted to the scientific examination of clinical disorders in taste, smell, and chemical irritation, as well as to basic research in the chemical senses in humans. Through the multi- disciplinary study of clinical populations, CCRC scientists expect to characterize and understand the etiologies of disorders in chemosensory function, provide information on mechanisms and functions of the chemical senses in humans, and develop strategies for treating/coping with chemosensory disorders. The purposed renewal of the CCRC will comprise an Administrative Core unit, a Sensory Core unit (which oversees the evaluation of referred patients with primary complaints of chemosensory disorders as well as refer patients to specific Projects), an three individual research projects. The general aims of the CCRC are: 1) to continue to provide a clinic facility for the evaluation of chemosensory disorders and the study of their etiologies and prognoses, with special emphasis on follow-up of patients and evaluating the quality of life of individuals with chemosensory disorders; 2) to continue to study human olfactory function at the cellular level, applying sensitive electrophysiological and biophysical techniques to human biopsy material collected from healthy young adults and aged individuals, and from patients with neurodegenerative diseases; 3) to increase our understanding of the role of peri-receptor events in the dynamic process of olfactory adaptation and recovery in patient and non-patient populations; 4) to continue unraveling the relationships between intranasal chemesthesis and olfaction, using referred anosmic patients and those with normal olfaction as experimental subjects.