Investigating novel hypoxia inducible factor (HIF) regulatory pathways in cancer

研究癌症中新型缺氧诱导因子 (HIF) 调节途径

• 批准号: 1941443
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1941443
• 关键词: Investigating; novel; hypoxia; inducible; factor

Cancer causes one in four of all deaths in the UK (Cancer Research UK) and is a disease of many diseases, each cancer type has a different genetic and biological profile. There is an unmet need for developing new therapeutic interventions that can be used to improve front-line treatments. A unifying feature found in cancers is hypoxia (low oxygen levels) Hypoxia leads to increased activation of hypoxia inducible factors (HIFs). Hypoxia and HIF activation is associated with treatment resistance and poor patient prognosis using front-line treatments (e.g. radiotherapy). While HIF itself is considered a challenging drug target, preventing HIF activation in cancer is an attractive strategy for the development of new anticancer agents. Thus elucidating the cellular processes underlying the regulation of HIF activity and HIF-mediated tumour progression are of particular interest therapeutically. The overall goal of the project will be to characterise novel HIF regulatory genes identified from a genetic screen.

在英国，四分之一的死亡是由癌症引起的（英国癌症研究所），癌症是多种疾病中的一种，每种癌症类型都有不同的遗传和生物学特征。开发可用于改善一线治疗的新治疗干预措施的需求尚未得到满足。在癌症中发现的一个统一特征是缺氧（低氧水平）。缺氧导致缺氧诱导因子（HIF）的活化增加。缺氧和HIF激活与使用一线治疗（例如放射疗法）的治疗抗性和不良患者预后相关。虽然HIF本身被认为是一个具有挑战性的药物靶点，但防止癌症中HIF活化是开发新抗癌药物的一个有吸引力的策略。因此，阐明HIF活性调节和HIF介导的肿瘤进展的细胞过程在治疗上特别感兴趣。该项目的总体目标将是从遗传筛选中鉴定新的HIF调控基因。

项目成果

Investigating the role of mitochondria in the hypoxia response using in vitro and in vivo models

使用体外和体内模型研究线粒体在缺氧反应中的作用

• 发表时间: 2022
• 作者: Al-Habib Alhasan

CHCHD4 (MIA40) and the mitochondrial disulfide relay system.

• DOI: 10.1042/bst20190232
• 发表时间: 2021-02-26
• 期刊: Biochemical Society transactions
• 影响因子: 3.9
• 作者: Al-Habib H;Ashcroft M
• 通讯作者: Ashcroft M