ROLE OF HUMAN MILK IN INFANT NUTRITION AND HEALTH

我们的计划项目资助申请的竞争性续签是 由调查人员提交，他们建议继续研究 人类乳汁的独特特性。所有的项目都涉及到生物 通过使用体外分析的方案产生的后果，动物 模特和人类。这些项目通常试图定义和描述 母乳中保护新生儿免受疾病侵袭的因素。一定的 腔内乳汁与胃肠道相互作用的后果 将继续审查与保护婴儿有关的问题。动物 将模型用于研究人类受试者是不可能的，但 只要合适，就会对人类婴儿进行研究。各自的 项目和分包合同将考虑：1)易溶牛奶的作用 预防志贺氏菌病的因素；2)抗炎 母乳的特性；3)分泌型免疫系统的作用 病毒肠道病原体感染；4)分离、鉴定和鉴定 母乳中热稳定性保护因子S的检测 大肠杆菌的肠毒素；以及5)母乳在预防 弯曲杆菌感染。每个项目都将得到 流行病学/统计学、生物化学和分子生物学核心 横断面。

The competitive renewal of our program project grant application is submitted by investigators who propose to continue their studies on the unique properties of human milk. All projects address the biologic consequences through protocols which utilize in vitro assays, animal models, and humans. The projects generally seek to define and characterize factors in human milk that protect newborn infants from disease. Certain consequences of the luminal milk gastrointestinal tract interactions that pertain to protection of the infant will continue to be examined. Animal models will be utilized with study of human subjects is not possible, but human infants will be studied whenever appropriate. The respective projects and subcontracts will consider: 1) the role of soluble milk factors in the prevention of shigellosis; 2) the anti-inflammatory characteristics of human milk; 3) the role of the secretory immune system in viral enteric pathogen infection; 4) isolation, characterization and testing of the protective factor(s) in human milk against heat-stable enterotoxin of E. coli; and 5) the role of human milk in the prevention of Campylobacter infection. Each of the projects will be supported by epidemiology/statistical, biochemical, and molecular biology core sections.