Core--Scientific

遗传/基因组数据分析核心的目的是提供严格和 有效地解决拟议中心及其个别项目的总体假设和目标 通过最先进的方法研究数量遗传学、基因组学、健康结果和综合 系统生物学。这一应用的总体假设是，上皮细胞基因在 过敏性疾病的发病机制和成功的治疗；每个项目都有明确的目标 阐述这一总体假设的不同方面。因此，这个核心的目的是：1)提供研究 为项目调查人员提供设计、数据管理和分析支持，以实现他们的特定目标；2) 整合在各个项目中收集的数据，从而进一步促进项目之间关于角色的互动 过敏性炎症中的上皮基因；以及3)促进更多的分析和研究， 支持该中心的中心主题和总体目标。为了实现这些目标，这一核心包括 一批经验丰富的教职员工，他们在统计分析、流行病学、 数量遗传学、基因组学、生物信息学和数据管理。核心调查人员将定期会面 相互之间，并在需要时与项目调查人员进行合作。这个核心的PI将与项目例行会面 领导层要保持问责，并优先重视对核心的研究支持。主要项目 本申请中所描述的涉及对来自病例对照和家庭的样本和数据的分析 这些研究是基于辛辛那提儿童过敏儿童的大量且不断增长的登记 精神错乱。这些项目将需要应用适合遗传流行病学的分析方法。 和微阵列研究，包括单变量比较和多变量建模以解释多个 适当的基因和/或环境因素。核心还将支持对现有的 以人群为基础的哮喘儿童队列研究以检验哮喘病例对照研究结果的重复性 在库拉纳的项目中进行的研究。

The purpose of the Genetic/Genomic Data Analysis core is to provide the capacity to rigorously and efficiently address the overall hypothesis and goals of the proposed Center and its individual projects through state of the art approaches to quantitative genetics, genomics, health outcomes and integrated systems biology. The overall hypothesis of this application is that epithelial cell genes play a central role in the pathogenesis and successful treatment of allergic disorders; each of the projects has specific aims that address different aspects of this overall hypothesis. The aims of this Core are thus to: 1) provide study design, data management, and analysis support to the project investigators to fulfill their specific aims; 2) integrate data collected in the individual projects and thereby further interactions among projects on the role of epithelial genes in allergic inflammation; and 3) promote additional analyses and investigations that support the central theme and overall goals of this center. To fulfill these aims, this core includes an experienced set of faculty and staff with recognized expertise in statistical analysis, epidemiology, quantitative genetics, genomics, bioinformatics, and data management. Core investigators will meet routinely with each other, and with project investigators as needed. The PI of this core will meet routinely with project leadership to maintain accountability and prioritize the research support of the core. The primary projects described in this application involve analysis of samples and data derived from case-control and family studies that are based on large and growing registries of children seen at Cincinnati Children's with allergic disorders. These projects will require application of analytic methods appropriate for genetic epidemiology and microarray studies, including univariate comparisons and multivariable modelling to account for multiple genes and/or environmental factors as appropriate. The core will also support analysis of an extant population-based cohort of asthmatic children to test the replication of findings of the asthma case-control study conducted in project by Khurana.