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CD8+ HELPER INDEPENDENT T CELLS IN TUMOR THERAPY

CD8+ HELPER INDEPENDENT T CELLS IN TUMOR THERAPY
CD8 辅助独立 T 细胞用于肿瘤治疗
批准号：
6489415
负责人：
PETER A COHEN
金额：
$29.97万
依托单位：
CLEVELAND CLINIC FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-01-01 至 2003-12-31
来源：
https://reporter.nih.gov/project-details/6489415
关键词：
RNase protection assay cytotoxic T lymphocyte enzyme inhibitors gene targeting genetically modified animals interleukin 2 interleukin 7 laboratory mouse lung neoplasms metastasis neoplasm /cancer immunotherapy neoplasm /cancer vaccine nonhuman therapy evaluation passive immunization polymerase chain reaction prostaglandin endoperoxide synthase sarcoma selectins vaccine development

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英文摘要
DESCRIPTION: The investigator proposes studies with L-selectin down regulated CD8+ T cells in mice to see whether their effectiveness can be improved with cytokines, examine the histology of tumors to see where administered CD8+ cells traffic, whether they undergo apoptosis or become tolerated at the tumor site. Dose-response studies with various numbers of T cells will also be performed against established tumors. The use of dendritic cells with peptides will also be explored to immunize the mice from which the T cells are obtained. Treatment of the tumor with cyclooxygenase inhibitors will also be studied to see whether tumor-induced suppression can be overcome.
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