Cytotoxic T lymphocyte synapse formation and serial killing: When breaking up is hard to do.

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Killer T cells are a specialised group of immune cells, which destroy cancerous and infected cells. When killer T cells find a target, they attach and secrete toxic molecules. It then detaches from the dying target, so that it may go on to kill other cells. If it doesn’t detach properly, it remains bound to the target cell and results in an improper immune response. This proposal will investigate how the killer cell detaches, which is essential for an efficient immune response.