Pathobiology of Mucosal/Epithelial Disease

描述(由申请人提供)： 这是对NRSA机构的竞争性续签申请，以支持四名医学博士和/或博士后研究员的培训。在过去的五年里，NIH赞助的这个奖项为12名研究员提供了支持，让他们在专注于上皮病理生物学领域的不同但综合的实验室小组中进行培训。我们已经完成了培养博士后研究员以便在学术界取得成功的目标。在这项NRSA资助的学员中，有7人在基础科学、临床医学和大学教学方面取得了成功。一个是科学课程评估员，一个是陆军研究员。其中三个正在进行高级研究培训。该项目的主要目标是在消化道粘膜疾病的病理生理学方面提供面向问题的研究的多学科培训，重点是上皮生物学，包括上皮细胞功能、炎症、病原体相互作用和肿瘤。培训学院由17名研究人员组成，他们拥有与这些研究领域相关的独立研究计划，他们提供了现代分子、免疫学和细胞生物学方法方面的专业知识，用于研究疾病的病理生理学。特别强调上皮生物学和免疫学，因为它与胃肠道疾病有关。培训计划的结构旨在继续促进参与培训的教员之间的互动，并为受训人员提供使用所有实验室及其大量资源的机会。受训人员将继续从全国范围内的临床和研究生项目中挑选出来，重点是确定合格的代表不足的少数民族。培训方案的主要组成部分是学员在他们选择的实验室进行的独立研究。通过参加几个可用的研究会议、期刊俱乐部和研讨会，以及参加埃默里大学研究生教育计划提供的课程，增强了培训体验，其中许多课程是由该培训计划的教员教授的。

DESCRIPTION (provided by applicant): This is a competing renewal application for an institutional NRSA to support the training of four MD and/or PhD postdoctoral fellows. Over the past five years, this NIH sponsored award has provided support for twelve fellows to train in a diverse yet integrated group of laboratories focused in the area of epithelial pathobiology. We have accomplished the goal of training postdoctoral fellows for successful careers in academia. Seven of the trainees who have been supported by this NRSA have gone on to careers in basic science, clinical medicine and university teaching. One is a science curriculum evaluator and one is a researcher for the Army. Three are pursuing advanced research training. The main goal of this program is to provide multidisciplinary training in problem oriented research on the pathophysiology of mucosal disease of the alimentary tract with special emphasis on epithelial biology, including epithelial cell function, inflammation, pathogen interactions and neoplasia. The training faculty consists of seventeen investigators with independent research programs related to these areas of study who provide expertise in modern molecular, immunologic and cell biologic approaches for studying the pathophysiology of disease. There exists particular emphasis on epithelial biology and immunology as it relates to disorders of the gastrointestinal tract. The structure of the training program is designed to continue to promote interactions among participating faculty and to provide trainees access to all of the laboratories and their considerable resources. Trainees will continue to be selected from clinical and graduate programs nationwide with emphasis on identifying qualified underrepresented minorities. The major component of the training program is independent research carried out by trainees in a laboratory of their choice. The training experience is enhanced by attendance at several available research conferences, journal clubs and seminars as well as attendance at courses provided by the graduate education program at Emory, many of which are taught by the faculty of this training program.