AMBIENT PARTICLES AND CARDIAC VULNERABILITY IN HUMANS

环境颗粒物与人类心脏脆弱性

• 批准号: 6382295
• 负责人: FRANK E SPEIZER
• 金额: $ 180万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-27 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6382295
• 关键词: air pollution; air sampling /monitoring; arrhythmia; clinical research; disease /disorder proneness /risk

Based on recent population-based studies of both morbidity and mortality, efforts have been directed toward understanding potential mechanisms whereby effects of exposure to ambient air pollutants could result in cardiovascular events. Our laboratory investigations have provided clues about potential autonomic nervous system responses that are modulated by the underlying pathophysiologic state of animals undergoing exposure to concentrated air particles. Testing these potential mechanisms in human populations requires a multidisciplinary approach joining epidemiologists, physiologists, cardiologists, ambient air monitoring specialists, and statisticians to develop protocols and carry Out investigations that will 1) characterize the physiologic state of at-risk groups; 2) mOnitOr exposure in sufficient detail to characterize and quantify the putative environmental agents; 3) make detailed and appropriately sustained measures of cardiac function that are relevant to assessing the autonomic response of the heart; and 4) correlate these potential findings with those found in animals exposed to concentrated air particles. Projects proposed will provide data on a spectrum of at-risk subjects that include patients with mild to moderately severe coronary artery disease, documented conduction defects, and elderly subjects with and without documented underlying cardiac disease. In subsequent years, we propose to expand the investigations to include other at-risk groups. Alternatively, some of these same groups of at-risk subjects can be studied in other regions of the country where the ambient particulate mix may be at higher levels or have different constituents. The projects are supported by: an Administrative and Statistical Core (Core 1) that will oversee the planning and analysis of the data; the Air Monitoring Core (Core 2) that will provide detailed characterizations and quantification of the participants' exposure; and the Cardiac Monitoring Core (Core 3) that will provide the electrocardiographic assessments. With the documentation of impacts of specific components of air pollutants on specific at-risk groups, these studies will provide additional insight into the understanding of the mechanisms whereby ambient pollution is associated with excess morbidity and mortality and may provide clues as to how to develop preventive strategies to reduce this excess.

基于最近的基于人群的发病率和死亡率的研究，努力已经指向了解潜在的机制，暴露于环境空气污染物的影响可能导致心血管事件。我们的实验室研究提供了线索，潜在的自主神经系统的反应，调制的基础病理生理状态的动物暴露于集中的空气颗粒。在人群中测试这些潜在的机制需要多学科的方法，包括流行病学家、生理学家、心脏病学家、环境空气监测专家和统计学家，以制定方案并进行调查，这些方案和调查将：1）表征高危人群的生理状态; 2）足够详细的mOnitOr暴露，以表征和量化推定的环境因子; 3）对心脏功能进行详细和适当的持续测量，这些测量与评估心脏的自主反应有关; 4）将这些潜在的发现与暴露于浓缩空气颗粒的动物中发现的发现相关联。拟议的项目将提供一系列高危受试者的数据，包括轻度至中度冠状动脉疾病患者、有记录的传导缺陷患者以及有或无记录的基础心脏疾病的老年受试者。在随后的几年里，我们建议扩大调查范围，以包括其他高危群体。或者，可以在该国的其他地区研究这些相同的高危受试者群体中的一些，这些地区的环境颗粒混合物可能处于更高水平或具有不同的成分。这些项目得到以下方面的支持：一个行政和统计核心（核心1），将监督数据的规划和分析;空气监测核心（核心2），将提供参与者暴露的详细特征和量化;心脏监测核心（核心3），将提供心电图评估。这些研究记录了空气污染物的特定成分对特定风险群体的影响，将进一步深入了解环境污染与过高的发病率和死亡率相关的机制，并可能为如何制定预防战略以减少这种过高的发病率和死亡率提供线索。