CORE--SIGNAL TRANSDUCTION RESEARCH FACILITY

这个核心的长期目标是阐明分子 非遗传毒性生物反应的潜在机制 环保人员。核心的目标是：1)描述信号 不同模型中的转导通路及其效应元件 系统：2)研究与疾病相关的分子机制 因此导致路径、效应器或信号传输中断 暴露在环境介质中；以及3)确定 遗传背景影响正常的信号转导途径。这个 需要解决的具体假设是，某些环境因素 通过干扰正常对照来改变基因表达 调节组织特异性受体和效应器分子的机制， 第二信使的产生、合成和激活 转录因子。该组织成员所进行的研究 来自四个不同部门的CORE正在解决这些问题。

The long-term objective of this Core is to elucidate the molecular mechanisms underlying the biological responses to non-genotoxic environmental agents. The aims of the Core are: 1) to delineate signal transduction pathways and their effector components in various model systems: 2) to study the molecular mechanisms associated with the disruption of pathways, effectors, or signal transmission as a consequence of exposure to environmental agents; and 3) to determine how variations in genetic background affect normal signal transduction pathways. The specific hypothesis to be addressed is that certain environmental agents act to modify gene expression by interfering with the normal control mechanisms that regulate tissue-specific receptors and effector molecules, production of second messengers, and synthesis and activation of transcription factors. The research conducted by the members of this Core, from four different departments, are addressing these issues.