CORE--SIGNAL TRANSDUCTION RESEARCH FACILITY

核心——信号传导研究设施

• 批准号: 6495683
• 负责人: Alvaro Puga
• 金额: $ 7.35万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6495683
• 关键词: apolipoproteins; biological signal transduction; biomedical facility; environmental toxicology; estrogens; genetic polymorphism; hormone receptor; human tissue; laboratory mouse; laboratory rat; receptor expression; reproduction; transcription factor

The long-term objective of this Core is to elucidate the molecular mechanisms underlying the biological responses to non-genotoxic environmental agents. The aims of the Core are: 1) to delineate signal transduction pathways and their effector components in various model systems: 2) to study the molecular mechanisms associated with the disruption of pathways, effectors, or signal transmission as a consequence of exposure to environmental agents; and 3) to determine how variations in genetic background affect normal signal transduction pathways. The specific hypothesis to be addressed is that certain environmental agents act to modify gene expression by interfering with the normal control mechanisms that regulate tissue-specific receptors and effector molecules, production of second messengers, and synthesis and activation of transcription factors. The research conducted by the members of this Core, from four different departments, are addressing these issues.

本核心的长期目标是阐明 非遗传毒性的生物学反应机制 环境代理人。 核心的目标是：1）描绘信号 各种模型中的转导途径及其效应成分 系统：2）研究与 结果是通路、效应器或信号传递中断 暴露于环境因素;和3）以确定如何变化， 遗传背景影响正常的信号转导通路。 的 要解决的具体假设是，某些环境因素 通过干扰正常对照来改变基因表达 调节组织特异性受体和效应分子的机制， 第二信使的产生， 转录因子 该组织成员进行的研究表明， 来自四个不同部门的核心正在解决这些问题。