Taking Inspiration from Nature for the Synthesis of Natural Products and Analogues

从大自然中获取灵感合成天然产物和类似物

• 批准号: 1945200
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1945200
• 关键词: Taking; Inspiration; Nature; Synthesis; Natural

Natural products and their derivatives continue to be important as leads for the discovery of new biologically active compounds as well as an inspiration for novel strategies in organic synthesis. This project builds upon preliminary results from investigations into the biosynthesis of the antibiotic abyssomicin C. It will include studies on the biosynthetic pathway to abyssomicin C and related compounds in which a Diels-Alder reaction is critical to assembly of the complex molecules. A combination of organic synthesis, spectroscopy and biotransformations will be used leading to clean and efficient methods to access a library of analogues. We aim to develop flow systems which will enable reactions to be performed on a synthetic useful scale.

天然产物及其衍生物仍然是发现新的生物活性化合物的重要线索，也是有机合成中新策略的灵感来源。这个项目建立在对抗生素abysSomicin C生物合成的初步研究结果的基础上，它将包括对abysSomicin C和相关化合物的生物合成途径的研究，其中Diels-Alder反应对复杂分子的组装至关重要。有机合成、光谱学和生物转化的结合将导致清洁和有效的方法来访问类似物的库。我们的目标是开发流动系统，使反应能够在合成的有用规模上进行。

项目成果

A Natural Diels-Alder Biocatalyst Enables Efficient [4+2] Cycloaddition Under Harsh Reaction Conditions

天然 Diels-Alder 生物催化剂可在恶劣的反应条件下实现高效的 [4 2] 环加成反应

• DOI: 10.1002/cctc.201901285
• 发表时间: 2019
• 期刊: ChemCatChem
• 影响因子: 4.5
• 作者: Marsh C