EPIDEMIOLOGIC STUDY OF THE LATE REPRODUCTIVE YEARS

描述：(改编自《调查者摘要》) 非裔美国人和高加索女性晚年卵巢老化的研究 生育年，从35-47岁开始，一直持续到45-52岁。这个 具体目标是1)比较激素动态(FSFL雌二醇、DHEAS)和 非裔美国人和高加索女性的卵泡抑制素；2) 评估研究期间的更年期相关症状，并比较他们的 非裔美国人和高加索女性之间的严重性和变化；以及 相关的生理和心理因素(身体质量、潮热、 抑郁、陡峭的精神障碍等)与激素水平、波动和 变化率并比较两个种族群体之间的联系。这个 这项研究是通过随机确定的基于人群的样本进行的 大约400名妇女。第二阶段的研究每年有四次 跟踪期间，每期两次，每隔1个月进行一次评估，总计 为荷尔蒙化验和问卷调查收集血液样本 数据。超过80%的美国女性经历过身体或心理上的 更年期症状有不同程度的严重和 扰乱正常的功能。这些症状是否通常归因于 更年期与荷尔蒙的变化有关。 生育年限还没有被很好地理解。降低质量的症状 生活对于经历过生活的女性来说是一个重大的问题，她们的 人际关系和他们的生产力。对症状和症状的了解较差 它们与生物和环境因素的联系是一个问题 当陷入困境的妇女寻求医疗救济时，医疗保健。这项研究提供了 关于症状之间联系的种族差异的第一个信息 以及非洲裔美国人和美国黑人之间荷尔蒙环境的变化 高加索女性。调查人员表示，这些发现也将告诉我们 临床医生解决育龄晚期妇女的生育问题 并将增加对生殖衰老在老年人中作用的理解 绝经后妇女发病率和死亡率增加。

DESCRIPTION: (Adapted from the Investigator's Abstract) This is a prospective study of ovarian aging in African American and Caucasian women in their late reproductive years, commencing at ages 35-47 and continuing to ages 45-52. The specific aims are to 1) compare hormone dynamics (FSFL estradiol, DHEAS) and the follicular product inhibin between African American and Caucasian women; 2) evaluate menopause-related symptoms over the study period and compare their severity and changes between African American and Caucasian women; and correlate physical and psychological factors (body mass, hot flashes, depression, steep disturbance and others) with hormone levels, fluctuations and rates of change and compare the associations between the two racial groups. The study is conducted with a randomly-identified population-based sample of approximately 400 women. The second phase of the study has four annual follow-up periods, each with two assessments at 1-month intervals, for a total of eight visits to collect blood samples for hormone assays and questionnaire data. More than 8O percent of U.S. women experience physical or psychological symptoms in the transition to menopause with varying degrees of severity and disruption of normal functioning. Whether these symptoms commonly attributed to the menopause are associated with the hormonal changes of the waning reproductive years is not well understood. Symptoms that diminish quality of life are a significant problem for women who experience them, their relationships and their productivity. Poor understanding of the symptoms and their associations with biological and environmental factors is a problem for health care when distressed women seek medical relief. This study provides the first information on racial differences in the associations between symptoms and the changing hormonal milieu compared between African American and Caucasian women. The investigators state that the findings will also inform clinicians addressing fertility problems of women in the late reproductive years and will increase understanding of the role of reproductive aging in the increased morbidity and mortality of postmenopausal women.