Epidemiologic Study of the Late Reproductive Years

这是一项关于卵巢老化的前瞻性队列研究的继续。这项研究的重点是激素 动态和相关症状作为绝经前妇女进入和通过阶段， 过渡到更年期。具体目标是：1））比较激素水平和纵向趋势 非裔美国人和高加索妇女之间的差异; 2）确定研究的妇女内部趋势 激素（雌二醇、FSH、LH、抑制素B、DHEAS和睾酮）和辅因子如BMI、种族、年龄， 症状等预测通过过渡的进展; 3）确定的协会， 与卵巢老化发生的身体和行为症状，并确定这些种族差异， 4）确定遗传多态性与水平和纵向趋势以及与 更年期症状激素评估和一系列的身体和行为评估是 每年在连续两个月经周期的第1-6天或在非月经周期女性中间隔1个月收集。 这项队列研究的继续将提供有关激素动力学及其对 更年期综合征的症状-你好... 超过80%的美国女性在更年期前后会出现身体或行为症状， 不同程度的严重性和功能中断，其中许多妇女寻求医疗救济 治疗痛苦的症状缺乏对这些症状的贡献者及其 卵巢衰老与激素因素的关联是一个重大的保健问题。增加 了解与生殖老化有关的变化，以及是否存在种族差异， 这些变化将导致更好的预防和治疗策略，以减少短期和长期的 妇女中年和绝经后的发病率。

This is a continuation of a prospective cohort study of ovarian aging. The study focuses on hormone dynamics and associated symptoms as premenopausalwomen enter and move through stages in the transition to menopause. The specific aims are to: 1)) Compare hormone levels and longitudinal trends between African American and Caucasian women; 2) Identify how within-woman trends of the study hormones (estradiol, FSH, LH, Inhibin B, DHEAS, and testosterone) and cofactors such as BMI, race, age, symptoms, et al predict the progression through the transition; 3) Identify associations of hormonedynamics with physical and behavioral symptoms that occur with ovarian aging and identify racial differences in these factors; 4) Identify associations of genetic polymorphisms with levels and longitudinal trends and with menopausal symptoms. Hormone evaluations and a battery of physical and behavioral assessmentsare collected annually on days 1-6 of two consecutive menstrual cycles or 1 month apart in non-cycling women. Continuation of this cohort study will provide new information on hormone dynamics and their influences on menopausal symptoms through the full menopausal transition.- ¿¿¿¿ ......... More than 80% of U.S. women experience physical or behavioral symptoms around menopause,with varying degrees of severity and disruption in their functioning, and many of these women seek medical relief for distressing symptoms. The lack of understanding of the contributors to these symptoms and their associations with hormonal factors of ovarian aging is a significant health care problem. Increased understanding of the changes associated with reproductive aging and whether there are racial differences in these changes will lead to better preventive and therapeutic strategies to reduce the short and long term morbidity of women's mid-life and postmenopausalyears.