Elucidating the mechanisms of alpha-conotoxin-induced calcium channel inhibition via G protein-coupled receptors

通过 G 蛋白偶联受体阐明 α-芋螺毒素诱导的钙通道抑制机制

• 批准号: nhmrc : 1034642
• 负责人: Dr Evan Thomas
• 金额: $ 27.94万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-mechanisms-alpha-coupled-receptors/110929
• 关键词: Elucidating; mechanisms; alpha; conotoxin; induced

N-type voltage-gated calcium channels (VGCCs) are membrane proteins involved in neurotransmission and play a major role in pain. VGCCs are a well-established target for the development of analgesics. Our recent research identified that VGCCs can be inhibited by ?-conotoxins from the venom of marine snails by targeting ?-aminobutyric acid receptors in sensory neurons. We will characterize this novel form of modulation of VGCCs by ?-conotoxins and define the pathways that lead to VGCC inhibition.

N型电压门控钙通道（VGCC）是参与神经传递的膜蛋白，在疼痛中起主要作用。VGCC是开发镇痛药的既定目标。我们最近的研究表明，VGCC可以被抑制？-芋螺毒素从海洋蜗牛的毒液通过靶向？感觉神经元中的氨基丁酸受体。我们将通过以下方式来描述这种新型的VGCC调制形式：芋螺毒素和定义的途径，导致VGCC抑制。