Investigating bacteroidetes gliding motility

研究拟杆菌的滑动运动

• 批准号: 1947216
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1947216
• 关键词: Investigating; bacteroidetes; gliding; motility

Bacteria is known to explore its milieu using pili or agella as motors. A somewhat more exotic and less studied form of movement is gliding motility. In the Bacteroidetes clade is a type of gliding motility that is powered by a secretion system. The mechanics of gliding motility are still mainly unknown, but it seems to crawl over surfaces much like a tank does, propelling adhesins in a helical path along the rod-shaped cell body and moves relative to those adhesins. In this research project, I will investigate the mechanisms by which the adhesins are secreted to, and propelled around, the cell surface. This is a basic science research project, underpinning the BBSRC research priorities "Animal health" and "Combating antimicrobial resistance".

众所周知，细菌使用菌毛或Agella作为发动机来探索其环境。滑行运动是一种更具异国情调、也较少被研究的运动形式。在拟杆菌中，分支是一种由分泌系统提供动力的滑行运动。滑行运动的机制主要尚不清楚，但它似乎像坦克一样在表面上爬行，沿着杆状细胞体以螺旋路径推动粘附素，并相对于这些粘附素移动。在这个研究项目中，我将研究粘附素被分泌到细胞表面并在细胞表面周围推进的机制。这是一个基础科学研究项目，是BBSRC研究优先事项“动物健康”和“抗击抗菌素耐药性”的基础。