Effects of Estrogen and Cannabinoids on Learning

雌激素和大麻素对学习的影响

• 批准号: 6515884
• 负责人: JILL M DANIEL
• 金额: $ 1.35万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6515884
• 关键词: autoradiography; behavioral /social science research tag; behavioral habituation /sensitization; brain; cannabinoid receptor; cannabinoids; central nervous system; estrogens; hippocampus; hormone regulation /control mechanism; hormone therapy; laboratory rat; learning; memory; ovariectomy; performance; receptor binding

DESCRIPTION (provided by applicant) There is growing evidence to indicate that there is an interaction between the biologically active constituent of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), and the ovarian hormone, estrogen, in the central nervous system. However, little information is currently available regarding the functional consequences of this interaction on behavior. Additionally, despite the fact that the behavioral effects of other drugs of abuse are influenced by estrogenic status, the behavioral effects of delta 9-THC in female animal models have not been investigated. The experiments in the proposed study will test the following hypotheses: 1) Estrogen replacement will attenuate the disruptive effects of systemically administered delta 9-THC on overall response rate and percent errors in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. 2) Estrogen replacement will differentially affect levels of cannabinoid receptor binding, as measured by quantitative receptor autoradiography, in brain areas implicated in learning and memory and will potentiate decreases in cannabinoid receptor binding induced by chronic administration of delta 9-THC. 3) Estrogen replacement will accelerate the development of delta 9-THC-induced behavioral tolerance in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. 4) Estrogen replacement will attenuate the disruptive effects of intrahippocampally-administered delta 9-THC on overall response rate and percent errors in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. These results will provide, for the first time, information regarding the interactive effects of estrogen and delta 9-THC on behavior.

描述（由申请人提供） 越来越多的证据表明， 大麻的生物活性成分，δ 9-四氢大麻酚 （δ 9-THC）和卵巢激素，雌激素，在中枢神经系统中 系统然而，目前关于这方面的资料很少。 这种相互作用对行为的功能性后果。此外，尽管 事实上，其他药物滥用的行为影响受到 雌激素状态，δ 9-THC对雌性动物行为的影响 模型没有被调查。拟议研究中的实验将 测试以下假设：1）雌激素替代会减弱 全身给予δ 9-THC对总体反应的破坏性作用 卵巢切除大鼠在多个 重复获取的时间表和行为链的表现。（二） 雌激素替代会不同程度地影响大麻素受体的水平 结合，通过定量受体放射自显影术测量，在脑区 参与学习和记忆，并将加强大麻素的减少 通过长期施用δ 9-THC诱导的受体结合。3)雌激素 替代将加速Δ 9-THC诱导的行为的发展 卵巢切除大鼠在多种时间表下的耐受性 行为链的重复获取和表现。4)雌激素 替换将减弱 腹膜内营地施用的Δ 9-THC对总体应答率的影响， 卵巢切除大鼠在多个时间表下反应的错误百分比 行为链的重复获取和表现。这些结果将 第一次提供关于互动影响的信息， 雌激素和δ 9-THC对行为的影响

项目成果

Effects of oestrogen on cognition: What have we learned from basic research?

• DOI: 10.1111/j.1365-2826.2006.01471.x
• 发表时间: 2006-10-01
• 期刊: JOURNAL OF NEUROENDOCRINOLOGY
• 影响因子: 3.2
• 作者: Daniel, J. M.