Administrative Core

行政核心（核心A）摘要 行政核心的目标是为国家提供领导和全面的行政管理， 该方案旨在确保实施方案项目的愿景，作为对下列问题的综合调查： 雌二醇对心脏代谢性疾病条件下大脑和认知轨迹影响的机制 健康和疾病。行政核心有以下具体目标。1)提供财政 为所有项目和核心提供管理和一般行政支助。行政核心将承担 该计划的财务责任，确保满足所有监管和报告要求，以及 管理日常的计划活动。2)提供专业的生物统计和实验设计支持。 行政核心将监督项目编制小组内使用的所有统计方法。这将包括方法 在项目中使用，也用于跨研究的比较。核心委员会将就研究设计和结果提供建议 报告. 3)对数据管理进行监督。行政核心将实施一项方案， 数据监测计划，将规定数据质量保证和质量控制的程序。核心 将监督数据安全，促进项目和核心之间的数据共享。核心还将确保 收集有效和可靠的数据。4)促进项目之间的沟通和协调， 丹行政核心将组织执行委员会的月度会议， 研究项目和核心领导人，每月计划范围内的科学会议，以及年度计划主办 研讨会5)组织和支持咨询委员会的会议。行政核心将是 负责与组织各内部委员会一年两次和一年一次的会议有关的后勤工作 和外部咨询委员会。6)提供和协调研究成果的联合传播计划。 行政核心将执行联合传播两个主要领域成果的程序： 提交专题讨论会提案和手稿。7)对该计划进行年度评估 项目行政核心将监督对所有项目和核心的年度审查。审查还将 包括衡量PPG作为协同研究计划的成功的指标。核心会产生 并向执行委员会和咨询委员会分发一份总结审查情况的报告。任何因此 将在行政核心的监督下执行改进建议。

Administrative Core (Core A) Summary The goal of the Administrative Core is to provide leadership and overall administrative management to the Program to ensure implementation of the vision of the Program Project as an integrated investigation of mechanisms of estradiol effects on the brain and cognitive trajectory under conditions of cardiometabolic health and disease. The Administrative Core has the following Specific Aims. 1) To provide financial management and general administrative support to all projects and cores. The Administrative Core will assume fiscal responsibility for the Program, ensure that all regulatory and reporting requirements are met, and manage the day-to-day Program activities. 2) To provide expert biostatistical and experimental design support. The Administrative Core will oversee all statistical approaches used within the PPG. This will include methods used within projects as well as for comparison across studies. The Core will advise on study design and results reporting. 3) To provide oversight of data management. The Administrative Core will implement a Program Data Monitoring Plan that will specify procedures for quality assurance and quality control of data. The Core will oversee data security and facilitate data sharing among the projects and cores. The Core will also ensure the collection of valid and reliable data. 4) To facilitate communication and coordination between projects and cores. The Administrative Core will organize monthly meetings of the Executive Committee that includes Research Project and Core Leads, monthly Program-wide scientific meetings, and an annual Program-hosted seminar. 5) To organize and support meetings of the Advisory Boards. The Administrative Core will be responsible for the logistics associated with organizing biannual and annual meetings of the respective Internal and External Advisory Committees. 6) To provide and coordinate plans for joint dissemination of study results. The Administrative Core will implement procedures for joint dissemination of results in two primary areas: joint submissions of symposia proposals and manuscripts. 7) To conduct an annual evaluation of the Program Project. The Administrative Core will oversee an annual review of all projects and cores. The review will also include metrics to measure the success of the PPG as a synergistic research program. The Core will generate and distribute a report summarizing the review to the Executive Committee and Advisory Boards. Any resulting recommendations for improvement will be implemented with oversight from the Administrative Core.