PSYCHOSOCIAL OUTCOMES IN CHILDHOOD CANCER SURVIVORS

儿童癌症幸存者的心理社会结局

• 批准号: 6514899
• 负责人: Bradley Jay Zebrack
• 金额: $ 4.42万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-08 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6514899
• 关键词: Hodgkin's disease; adult human (21+); alcoholism /alcohol abuse; anxiety; behavioral /social science research tag; chronic pain; clinical research; depression; exercise; health care service utilization; human subject; leukemia; long term survivor; nonHodgkin's lymphoma; outcomes research; pediatric neoplasm /cancer; psychological aspect of cancer; quality of life; siblings; smoking; tobacco abuse

The purpose of this proposal is to further understanding of the prevalence, characteristics and predictors of the psychosocial health status, health risk behaviors and neurological sequelae of long-term survivors of childhood cancer. The research proposed in this application will make use of the Childhood Cancer Survivor Study, a multi-institutional collaborative project that has established and followed a retrospectively-ascertained cohort of long-term survivors of childhood cancer and 6,000 sibling controls. This is the largest sample of well-characterized childhood cancer survivors and sibling controls known to date. Previous work suggests that certain subsets of childhood cancer survivors are vulnerable to a variety of physical and psychosocial problems, but the generalizability of these findings are limited by small sample sizes, data derived from single institutions, and lack of a control group. Furthermore, study in this field has yet to identify critical variables that influence (1) long-term survivors' psychosocial problems, but the generalizability of these findings are limited by small sample sizes, data derived from single institutions, and lack of a control group. Furthermore, study in this field has yet to identify critical variables that influence (1) long-term survivors' psychosocial status/quality of life, including their experiences with pain, and (2) behaviors that place them at risk for future health problems. The work to be conducted during the period of this functioning, and health behaviors. Physical, psychological, social and neurological factors that potentially influence these outcomes will be investigated. Specific hypotheses related to these outcomes are proposed and potentially moderating and mediating factors will be investigated. Psychosocial support interventions throughout a continuum of care- from diagnosis through treatment and into long-term survivorship-will be suggested. Plans for intervention research will be forthcoming.

本研究旨在进一步了解儿童癌症长期存活者的心理社会健康状况、健康危险行为和神经后遗症的患病率、特点和预测因素。这项申请中提出的研究将利用儿童癌症幸存者研究，这是一个多机构合作项目，已经建立并跟踪了儿童癌症长期幸存者和6000名兄弟姐妹对照的回顾确定的队列。这是迄今为止已知的具有良好特征的儿童癌症幸存者和兄弟姐妹对照的最大样本。以前的工作表明，儿童癌症幸存者的某些亚群容易受到各种身体和心理社会问题的影响，但这些发现的普遍性受到样本量小、来自单一机构的数据以及缺乏对照小组的限制。此外，这一领域的研究尚未确定影响(1)长期幸存者的心理社会问题的关键变量，但这些发现的普适性受到样本量小、来自单一机构的数据以及缺乏控制组的限制。此外，这一领域的研究尚未确定影响(1)长期幸存者的心理社会地位/生活质量，包括他们的疼痛经历，以及(2)将他们置于未来健康问题风险中的行为的关键变量。在此期间要开展的工作，以及健康行为。将对可能影响这些结果的生理、心理、社会和神经因素进行调查。与这些结果相关的具体假设被提出，潜在的调节和中介因素将被调查。将建议在整个护理连续过程中进行心理社会支持干预--从诊断到治疗再到长期生存。干预研究的计划即将出台。