Social genomic mechanisms of health disparities among Adolescent and Young Adult (AYA) cancer survivors
青少年和青年(AYA)癌症幸存者健康差异的社会基因组机制
基本信息
- 批准号:10487418
- 负责人:
- 金额:$ 89.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-10 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescenceAdolescent and Young AdultAdult LymphomaAffectAftercareAgeAmerican College of Radiology Imaging NetworkAntiviral resistanceBiologicalBiological AssayBiologyBloodBlood specimenCancer ModelCancer SurvivorCancer SurvivorshipCaringCellsChildhoodChronic DiseaseCollaborationsCommunity Clinical Oncology ProgramCoping BehaviorDataData SetDevelopmentDiscriminationDisease ProgressionEastern Cooperative Oncology GroupEndocrineEnvironmental Risk FactorEthnic OriginExposure toFibrinogenFutureGenderGender IdentityGene ExpressionGene Expression RegulationGenesGenetic TranscriptionGeographic LocationsGeographyGoalsHealthHeterogeneityHodgkin DiseaseHumanImmuneIndividualInflammationInflammatoryInterferon Type IInterventionInvestigationLate EffectsLifeLiteratureLong-Term EffectsLongitudinal cohort studyMalignant NeoplasmsMapsMeasuresMedicalMental HealthMolecularMolecular TargetMorbidity - disease rateNational Cancer InstituteNeoplasm MetastasisNon-Hodgkin&aposs LymphomaOncologyOutcomePathway interactionsPatientsPersonal SatisfactionPopulationPositioning AttributePovertyProcessProspective cohort studyPsychological FactorsQuality of lifeRaceReportingResearchResearch InfrastructureRiskRisk FactorsRoleRuralSelf EfficacySocial ConditionsSocial EnvironmentSocial FunctioningSocial isolationSocial supportStructureSupportive careSurvivorsSymptomsTreatment/Psychosocial EffectsTumor TissueVulnerable PopulationsWorkadolescent health outcomesbasecancer diagnosiscancer recurrencecancer therapychildhood adversityearly childhoodexperiencefunctional genomicsgenome-widegenomic profileshealth disparityimmune functionimprovedknowledge basemortalitynovelpediatric traumaperceived discriminationphysical conditioningpopulation healthprogramspsychologicpsychosocialpsychosocial stressorsrecruitrelating to nervous systemresilienceresponsesexsocialsocial engagementsocial factorssocial genomicssocial health determinantssocioeconomic disadvantagesocioeconomicssurvivorshiptherapy resistanttranscriptometrauma exposuretreatment effecttumor progressionyoung adult
项目摘要
Social genomic mechanisms of health disparities among Adolescent and Young Adult (AYA) cancer
survivors.
Survivors of cancer diagnosed in adolescence or young adulthood have an elevated risk of multiple health
problems. They also experience specific and unique psychosocial stressors and life disruptions having
ramifications for their health, mental health, and quality of life (QOL). These outcomes, and disparities in these
outcomes (by race/ethnicity, sex and gender, geographic location), may be partially a function of social
determinants of health, including socioeconomic gradients, exposures to early childhood traumas or adversity,
and accumulated experiences of discrimination. Yet, little is known about these effects including the biological
pathways through which the known effects of social-environmental risk factors on population health and well-
being influence outcomes in post-treatment AYA cancer survivors, particularly with regard to morbidity, mortality,
and QOL. Therefore, the research proposed here is intended to identify and define functional genomic pathways
through which current and past psychosocial and social environmental risk and resilience factors influence gene
regulation in AYAs, and thus contribute to a greater understanding of health disparities in post-treatment
survivorship. We propose a 5-year longitudinal prospective cohort study of 2000 AYA cancer survivors recruited
within one year following completion of treatment for Hodgkin or non-Hodgkin lymphomas. Using repeated
measures of risk and resilience factors and blood assays, we will evaluate the extent to which biological,
psychological and social indicators are associated with, and potentially predict, mortality and morbidity in AYA
cancer survivors within two years following completion of therapy. In collaboration with the Eastern Cooperative
Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) research infrastructure and
the National Cancer Institute Community Oncology Research Program (NCORP), this study will 1) identify the
genome-wide transcriptional impact of social-environmental RISK factors (i.e., adverse living conditions/poverty,
childhood trauma exposure, social isolation, and discrimination) and define the relationships of those genomic
profiles to AYA survivor mortality, morbidity, and QOL; 2) identify the genome-wide transcriptional impact of
individual RESILIENCE factors (i.e., social support, sense of purpose/meaning-making, self-efficacy) and define
the relationships of those genomic profiles to AYA mortality, morbidity, and QOL; and, 3) identify the genome-
wide molecular correlates of vulnerable populations, as structured by race/ethnicity, sexual/gender identity, and
geography (e.g., rural vs. urban), and define the relationships of those genomic profiles to AYA survivor mortality,
morbidity, and QOL. The study results may inform the conceptualization and development of new biological /
molecular targets for future interventions to reduce risks for long-term and late effects of treatment and maximize
likelihood of long-term health and QOL for AYA cancer survivors.
青春期和青壮年(Aya)癌症健康差异的社会基因组机制
幸存者。
在青春期或青春期被诊断为癌症的幸存者有更高的多重健康风险
有问题。他们还会经历特定和独特的心理社会压力和生活中断
对他们的健康、心理健康和生活质量(QOL)的影响。这些结果,以及这些结果之间的差距
结果(按种族/族裔、性别和性别、地理位置)可能在一定程度上是社会的功能
健康的决定因素,包括社会经济梯度、儿童早期创伤或逆境的暴露,
并积累了歧视的经验。然而,人们对这些影响知之甚少,包括生物学上的
已知的社会环境风险因素对人群健康和健康的影响途径
影响治疗后癌症幸存者的结局,特别是在发病率、死亡率、
和生活质量。因此,这里提出的研究旨在识别和定义功能基因组途径
现在和过去的心理社会和社会环境风险和复原力因素通过什么影响基因
AYA的监管,从而有助于更好地了解治疗后的健康差距
生存能力。我们建议对招募的2000名癌症幸存者进行为期5年的纵向前瞻性队列研究。
在完成霍奇金或非霍奇金淋巴瘤治疗后一年内。使用重复的
风险和复原力因素的衡量以及血液分析,我们将评估生物学、
心理和社会指标与阿亚的死亡率和发病率相关,并有可能预测死亡率和发病率
癌症幸存者在完成治疗后的两年内。与东方合作社合作
肿瘤学小组-美国放射成像学院网络(ECOG-ACRIN)研究基础设施和
国家癌症研究所社区肿瘤学研究计划(NCORP),这项研究将1)确定
社会-环境风险因素(例如,不利的生活条件/贫困,
童年创伤暴露、社会孤立和歧视),并定义了这些基因组之间的关系
对AYA幸存者死亡率、发病率和生活质量的影响;2)确定AYA对全基因组转录的影响
个人复原力因素(即社会支持、使命感/意义创造、自我效能)和定义
这些基因组图谱与AYA死亡率、发病率和生活质量的关系;以及,3)识别基因组-
弱势群体的广泛分子关联,如种族/族裔、性/性别认同以及
地理位置(例如,农村与城市),并定义这些基因组图谱与Aya幸存者死亡率的关系,
发病率和生活质量。研究结果可为新生物医学的构思和发展提供参考。
未来干预的分子目标,以降低治疗的长期和晚期影响的风险,并最大限度地提高
Aya癌症幸存者长期健康和生活质量的可能性。
项目成果
期刊论文数量(0)
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Bradley Jay Zebrack其他文献
Bradley Jay Zebrack的其他文献
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{{ truncateString('Bradley Jay Zebrack', 18)}}的其他基金
Social genomic mechanisms of health disparities among Adolescent and Young Adult (AYA) cancer survivors
青少年和青年(AYA)癌症幸存者健康差异的社会基因组机制
- 批准号:
10272690 - 财政年份:2021
- 资助金额:
$ 89.83万 - 项目类别:
Quality of Life Assessment in Childhood Cancer Survivors
儿童癌症幸存者的生活质量评估
- 批准号:
6601151 - 财政年份:2003
- 资助金额:
$ 89.83万 - 项目类别:
Quality of Life Assessment in Childhood Cancer Survivors
儿童癌症幸存者的生活质量评估
- 批准号:
7101827 - 财政年份:2003
- 资助金额:
$ 89.83万 - 项目类别:
Quality of Life Assessment in Childhood Cancer Survivors
儿童癌症幸存者的生活质量评估
- 批准号:
7749341 - 财政年份:2003
- 资助金额:
$ 89.83万 - 项目类别:
Quality of Life Assessment in Childhood Cancer Survivors
儿童癌症幸存者的生活质量评估
- 批准号:
6800463 - 财政年份:2003
- 资助金额:
$ 89.83万 - 项目类别:
Quality of Life Assessment in Childhood Cancer Survivors
儿童癌症幸存者的生活质量评估
- 批准号:
7278271 - 财政年份:2003
- 资助金额:
$ 89.83万 - 项目类别:
Quality of Life Assessment in Childhood Cancer Survivors
儿童癌症幸存者的生活质量评估
- 批准号:
6943533 - 财政年份:2003
- 资助金额:
$ 89.83万 - 项目类别:
PSYCHOSOCIAL OUTCOMES IN CHILDHOOD CANCER SURVIVORS
儿童癌症幸存者的心理社会结局
- 批准号:
6514899 - 财政年份:2002
- 资助金额:
$ 89.83万 - 项目类别:
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