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FUNCTION OF THE BACULOVIRUS MEMBRANE FUSION PROTEIN

FUNCTION OF THE BACULOVIRUS MEMBRANE FUSION PROTEIN
杆状病毒膜融合蛋白的功能
批准号：
6510643
负责人：
GARY W BLISSARD
金额：
$16.85万
依托单位：
BOYCE THOMPSON INST FOR PLANT RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-08-01 至 2004-03-31
来源：
https://reporter.nih.gov/project-details/6510643
关键词：
Baculoviridae X ray crystallography binding proteins fluorescence microscopy gene mutation immunoelectron microscopy immunoprecipitation membrane fusion membrane proteins molecular cloning nucleic acid sequence protein structure function receptor binding site directed mutagenesis tissue /cell culture virus assembly virus envelope virus infection mechanism virus protein virus replication yeast two hybrid system

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中文摘要
翻译
描述(改编自申请人的摘要)：杆状病毒是高毒力的昆虫病毒，其用作生物防治剂和重要的表达载体。作为致病性昆虫病毒，杆状病毒是研究病毒与昆虫组织和细胞相互作用的优秀模型系统。我们的研究集中在芽生病毒颗粒的主要包膜蛋白 GP64 上。 GP64蛋白似乎在感染周期中发挥多种功能：1）识别宿主细胞受体分子； 2）病毒进入过程中病毒与宿主膜的融合； 3) 参与病毒的出芽或组装。
英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): Baculoviruses are highly virulent insect viruses that serve as biological control agents and as important expression vectors. As pathogenic insect viruses, baculoviruses serve as excellent model systems for studies of viral interactions with insect tissues and cells. Our studies have focused on the major envelope protein, GP64, of the budded virus particle. The GP64 protein appears to serve a number of functions in the infection cycle: 1) recognition of the host cell receptor molecules; 2) fusion of viral and host membranes during virus entry; and, 3) participation in budding or assembly of the virus.
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FUNCTION OF THE BACULOVIRUS MEMBRANE FUSION PROTEIN
Baculovirus envelope proteins and insect cells
Baculovirus envelope proteins and insect cells
Baculovirus envelope proteins and insect cells
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