TRAINING PROGRAM IN BIOMOLECULAR SIGNAL TRANSDUCTION

生物分子信号转导可以被定义为细胞外或细胞内成分与细胞分子之间在分子水平上的相互作用，从而导致细胞活动的变化。这包括生长因子与细胞膜受体的结合，第二信使与细胞内蛋白质的结合，或连接或激活的反式激活剂与DNA和/或相关蛋白质的相互作用。信号转导包括所有形式的细胞外和细胞内通讯。因此，这一领域的培训需要一名研究涵盖信号转导许多方面的教师。该培训基金的教职员工来自基默癌症研究所和生物化学和分子药理学系的成员。自从这笔拨款开始以来，这一领域取得了巨大的进展，以至于信号转导的主题分支到现代生物学的大多数努力中。利用托马斯·杰斐逊大学精选的教员培训未来的独立研究人员现在包括两个研究生课程：生物化学和分子生物学、药理学和结构生物学。博士前学生必须完成一系列严格的研究生课程，提供全面的生物化学、分子生物学和细胞生物学背景。在托马斯·杰斐逊大学研究生院的博士课程的第二年，会有更多的专业课程。学生以文献为基础举办研讨会，然后持续举办以拟议研究和正在进行的研究为基础的研讨会。研究培训是导师式的，研究型学生咨询委员会积极参与。结合这个委员会的意见，研究生将根据以前的经验和具体兴趣来调整他/她的课程。研究生研究委员会将监督课程调整。攻读博士学位的课程向希望进入生物医学研究的认可机构持有学士或硕士学位的学生开放，也向希望成为独立科学研究人员的专业学位(M.D.、D.O.、D.V.M.ir D.D.S)持有者开放。只有全日制学生才能入学。平均绩点、GRE成绩、推荐信、研究兴趣声明、以前的研究经验和面试是录取的重要标准。一般来说，本科生的GPA为3.0或更高，累计GRE为1800或更高，尽管在选择时可能会权衡研究经验。博士后申请者必须拥有博士、医学博士、法学博士、法学博士或医学硕士学位。过去的研究经验和教育培训将决定博士后计划。该计划的目标是培养训练有素、技术能力强的研究科学家，他们能够执行并最终指导生物分子信号转导领域的研究。

Biomolecular signal transduction can be defined as interactions at the molecular level between extracellular components or intracellular components and cellular molecules that result in changes in cellular activities. This includes binding of growth factors to cell membrane receptors, the binding of second messengers to intracellular proteins or the interaction of liganded or activated transactivators with DNA and/or associated proteins. Signal transduction includes all forms of extracellular and intracellular communication. Thus, training in this field requires a faculty whose research encompasses many aspects of signal transduction. Faculty of this training grant are drawn from members of the Kimmer Cancer Institute and the Department of Biochemistry and Molecular Pharmacology. Since the inception of this grant, there has been enormous progress in this field so that the topic of signal transduction ramifies into most endeavors in modern biology. Training future independent investigators utilizing selected faculty of Thomas Jefferson University now spans two graduate programs: Biochemistry and Molecular Biology Pharmacology and Structural Biology. Predoctoral students must completed a rigorous series of graduate courses providing a thorough background in biochemistry, molecular biology and cell biology. More specialized courses follow in the second year within Ph.D. programs in the College of Graduate Studies of Thomas Jefferson University. Students present seminars based on literature and later, on a continuing basis, seminars based on proposed research and research in progress. Research training is of the preceptor type with active participation of the Research Student Advisory Committees. Together with the input of this committee the graduate student will tailor his/her curriculum depending on prior experience and specific interest. The Graduate Studies Committee will oversee curricular adjustments. The program of study leading to the Ph.D. degree is open to students holding a Bachelor's or Master's degree from an accredited institution who wish to enter biomedical research as well as to professional degree (M.D., D.O., D.V.M ir D.D.S) holders who wish to become independent scientific investigators. Only full-time students are accepted. Grade point average, GRE scores, letters of recommendation, statement of research interest, prior research experience and an interview are important criteria for acceptance. In general, undergraduates have a 3.0 GPA or better and a cumulative GRE of 1800 or better, although research experience may be weighed into selection. Postdoctoral applicants must hold a Ph.D., M.D., D.O., D.D.S. or D.V.M. degree. Past research experience and educational training will determine the post-doctoral program. The goal of this program is to develop highly trained, technically competent research scientists cap[able of performing and eventually directing research in the area of biomolecular signal transduction.