TRAINING PROGRAM IN BIOMOLECULAR SIGNAL TRANSDUCTION

生物分子信号转导是指细胞外或细胞内成分与细胞分子之间在分子水平上的相互作用，导致细胞活性的变化。这包括生长因子与细胞膜受体的结合、第二信使与细胞内蛋白质的结合或配体化或活化的反式激活因子与DNA和/或相关蛋白质的相互作用。信号转导包括所有形式的细胞外和细胞内通讯。因此，在这一领域的培训需要一个教师，其研究包括信号转导的许多方面。该培训补助金的教员来自Kimmer癌症研究所和生物化学与分子药理学系的成员。自该基金设立以来，在这一领域取得了巨大的进展，因此信号转导的主题在现代生物学中得到了广泛的应用。利用托马斯杰斐逊大学的选定教师培训未来的独立调查人员现在跨越两个研究生课程：生物化学和分子生物学药理学和结构生物学。博士预科生必须完成一系列严格的研究生课程，提供生物化学，分子生物学和细胞生物学的全面背景。更多的专业课程在博士学位的第二年进行。托马斯杰斐逊大学研究生院的课程。学生目前的研讨会的基础上的文献，后来，在持续的基础上，研讨会的基础上提出的研究和研究进展。研究培训是导师型的，研究学生咨询委员会积极参与。与该委员会的投入一起，研究生将根据以前的经验和具体兴趣定制他/她的课程。研究生学习委员会将监督课程调整。攻读博士学位的课程。学位是开放给学生持有学士或硕士学位，从认可的机构谁希望进入生物医学研究以及专业学位（医学博士，D.O.，D. V. M或D.D.S）持有者，希望成为独立的科学研究者。只接受全日制学生。平均成绩，GRE成绩，推荐信，研究兴趣陈述，先前的研究经验和面试是录取的重要标准。一般来说，本科生的GPA为3.0或更高，累计GRE为1800或更高，尽管研究经验可能会被考虑在内。博士后申请人必须持有博士学位，医学博士，D.O.，D.D.S.或DVM℃下过去的研究经验和教育培训将决定博士后计划。该计划的目标是培养训练有素，技术能力强的研究科学家帽[能够执行并最终指导生物分子信号转导领域的研究。

Biomolecular signal transduction can be defined as interactions at the molecular level between extracellular components or intracellular components and cellular molecules that result in changes in cellular activities. This includes binding of growth factors to cell membrane receptors, the binding of second messengers to intracellular proteins or the interaction of liganded or activated transactivators with DNA and/or associated proteins. Signal transduction includes all forms of extracellular and intracellular communication. Thus, training in this field requires a faculty whose research encompasses many aspects of signal transduction. Faculty of this training grant are drawn from members of the Kimmer Cancer Institute and the Department of Biochemistry and Molecular Pharmacology. Since the inception of this grant, there has been enormous progress in this field so that the topic of signal transduction ramifies into most endeavors in modern biology. Training future independent investigators utilizing selected faculty of Thomas Jefferson University now spans two graduate programs: Biochemistry and Molecular Biology Pharmacology and Structural Biology. Predoctoral students must completed a rigorous series of graduate courses providing a thorough background in biochemistry, molecular biology and cell biology. More specialized courses follow in the second year within Ph.D. programs in the College of Graduate Studies of Thomas Jefferson University. Students present seminars based on literature and later, on a continuing basis, seminars based on proposed research and research in progress. Research training is of the preceptor type with active participation of the Research Student Advisory Committees. Together with the input of this committee the graduate student will tailor his/her curriculum depending on prior experience and specific interest. The Graduate Studies Committee will oversee curricular adjustments. The program of study leading to the Ph.D. degree is open to students holding a Bachelor's or Master's degree from an accredited institution who wish to enter biomedical research as well as to professional degree (M.D., D.O., D.V.M ir D.D.S) holders who wish to become independent scientific investigators. Only full-time students are accepted. Grade point average, GRE scores, letters of recommendation, statement of research interest, prior research experience and an interview are important criteria for acceptance. In general, undergraduates have a 3.0 GPA or better and a cumulative GRE of 1800 or better, although research experience may be weighed into selection. Postdoctoral applicants must hold a Ph.D., M.D., D.O., D.D.S. or D.V.M. degree. Past research experience and educational training will determine the post-doctoral program. The goal of this program is to develop highly trained, technically competent research scientists cap[able of performing and eventually directing research in the area of biomolecular signal transduction.