TRAINING PROGRAM IN BIOMOLECULAR SIGNAL TRANSDUCTION

生物分子信号转导培训计划

• 批准号: 6516898
• 负责人: GERALD LITWACK
• 金额: $ 25.35万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516898
• 关键词: TRAINING; PROGRAM; BIOMOLECULAR; SIGNAL; TRANSDUCTION

Biomolecular signal transduction can be defined as interactions at the molecular level between extracellular components or intracellular components and cellular molecules that result in changes in cellular activities. This includes binding of growth factors to cell membrane receptors, the binding of second messengers to intracellular proteins or the interaction of liganded or activated transactivators with DNA and/or associated proteins. Signal transduction includes all forms of extracellular and intracellular communication. Thus, training in this field requires a faculty whose research encompasses many aspects of signal transduction. Faculty of this training grant are drawn from members of the Kimmer Cancer Institute and the Department of Biochemistry and Molecular Pharmacology. Since the inception of this grant, there has been enormous progress in this field so that the topic of signal transduction ramifies into most endeavors in modern biology. Training future independent investigators utilizing selected faculty of Thomas Jefferson University now spans two graduate programs: Biochemistry and Molecular Biology Pharmacology and Structural Biology. Predoctoral students must completed a rigorous series of graduate courses providing a thorough background in biochemistry, molecular biology and cell biology. More specialized courses follow in the second year within Ph.D. programs in the College of Graduate Studies of Thomas Jefferson University. Students present seminars based on literature and later, on a continuing basis, seminars based on proposed research and research in progress. Research training is of the preceptor type with active participation of the Research Student Advisory Committees. Together with the input of this committee the graduate student will tailor his/her curriculum depending on prior experience and specific interest. The Graduate Studies Committee will oversee curricular adjustments. The program of study leading to the Ph.D. degree is open to students holding a Bachelor's or Master's degree from an accredited institution who wish to enter biomedical research as well as to professional degree (M.D., D.O., D.V.M ir D.D.S) holders who wish to become independent scientific investigators. Only full-time students are accepted. Grade point average, GRE scores, letters of recommendation, statement of research interest, prior research experience and an interview are important criteria for acceptance. In general, undergraduates have a 3.0 GPA or better and a cumulative GRE of 1800 or better, although research experience may be weighed into selection. Postdoctoral applicants must hold a Ph.D., M.D., D.O., D.D.S. or D.V.M. degree. Past research experience and educational training will determine the post-doctoral program. The goal of this program is to develop highly trained, technically competent research scientists cap[able of performing and eventually directing research in the area of biomolecular signal transduction.

生物分子信号转导可以定义为细胞外成分或细胞内成分与细胞分子在分子水平上的相互作用，导致细胞活动的变化。这包括生长因子与细胞膜受体的结合，第二信使与细胞内蛋白的结合，配体或活化的反激活子与DNA和/或相关蛋白的相互作用。信号转导包括所有形式的细胞外和细胞内通讯。因此，这一领域的培训需要一个研究涵盖信号转导许多方面的教师。这项培训经费来自基默癌症研究所和生物化学和分子药理学部门的成员。自该基金成立以来，该领域已经取得了巨大的进展，因此信号转导的主题成为现代生物学中最努力的课题。利用托马斯·杰斐逊大学选定的教师培养未来的独立研究者，现在跨越了两个研究生课程：生物化学和分子生物学药理学和结构生物学。博士生必须完成一系列严格的研究生课程，提供生物化学，分子生物学和细胞生物学的全面背景。在托马斯·杰斐逊大学研究生院的博士课程中，第二年有更专业的课程。学生们以文献为基础进行研讨会，随后，在持续的基础上，以拟议的研究和正在进行的研究为基础进行研讨会。研究训练是导师式的，研究学生咨询委员会积极参与。在这个委员会的指导下，研究生将根据之前的经验和具体兴趣定制他/她的课程。研究生学习委员会将监督课程的调整。攻读博士学位的课程对持有认可机构的学士或硕士学位的学生开放，这些学生希望进入生物医学研究领域，也对希望成为独立科学研究者的专业学位（医学博士、医学博士、医学博士或医学博士）开放。只接受全日制学生。平均成绩、GRE成绩、推荐信、研究兴趣陈述、之前的研究经验和面试是录取的重要标准。一般来说，本科生的平均绩点要达到3.0或更高，GRE成绩要达到1800或更高，尽管研究经验可能会被考虑在内。博士后申请者必须具有博士学位、医学博士学位、医学博士学位、医学博士学位或医学博士学位。过去的研究经验和教育培训将决定博士后项目。该计划的目标是培养训练有素，技术能力强的研究科学家，能够在生物分子信号转导领域进行并最终指导研究。