University Training Program in Biomolecular and Tissue Engineering
生物分子和组织工程大学培训计划
基本信息
- 批准号:10652660
- 负责人:
- 金额:$ 53.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY/ABSTRACT
The current proposal seeks to continue support of the long-standing biotechnology training program
administered by the Center for Biomolecular and Tissue Engineering (CBTE) at Duke University. The
objective of this biotechnology training program is to provide predoctoral training in the classroom,
laboratory, and scientific community in the design, manipulation, and quantitative characterization of
biomolecules, cells and tissues with special emphasis on the translation of these technologies and their
advancement within the biotechnology industry. Training activities are focused on enhancing and diversifying
our biotechnology work force and preparing the next generation of leaders who will pioneer burgeoning new
fields such as biologic drug development, tissue engineering, and gene and cell therapy. Participating
predoctoral trainees are required to meet the following criteria: (1) perform research that is
interdisciplinary in nature and is central to the development of innovative biotechnology; (2) have at least
two CBTE faculty, one from biomedical sciences and one from engineering, on their doctoral dissertation
committee; (3) present in the monthly work-in-progress student seminar series; (4) complete engineering
and biomedical science courses that provide breadth in biomolecular and tissue engineering; (5) complete
four semesters of the interdisciplinary CBTE seminar series for credit, including dedicated meetings with
visiting speakers; (6) participate in a three-month industrial biotechnology internship; (7) present in the
annual CBTE Distinguished Lecture and Symposium; (8) attend regularly scheduled biotechnology-
focused career development seminars and workshops; and (9) undergo training in responsible conduct
and rigor and reproducibility in research. This interdisciplinary training program includes 37 faculty across
campus, with 22 faculty from the Pratt School of Engineering and 15 faculty from non-engineering fields,
including 5 in the Trinity College of Arts & Sciences, and 10 in the Basic Medical Science and Clinical
Departments of the Duke University Medical Center. Over the past 26 years, a total of 116 students have
received predoctoral traineeships in biomolecular and tissue engineering. The majority of our trainees
have obtained positions as leaders in the biotech industry, including as co-founders of new companies
and pioneers in new areas of biotechnology, while others have pursued careers in academic, medicine, or
government. A hallmark of our program has been the increased diversity of trainee cohort over time.
Collectively, these activities decidedly increase the value of the education and preparation of our trainees
for careers in the biotechnology industry and other fields, as demonstrated by our extensive track record
and quantitative outcome measures.
项目总结/摘要
目前的提案寻求继续支持长期存在的生物技术培训计划
由杜克大学的生物分子和组织工程中心(CBTE)管理。的
该生物技术培训计划的目标是在课堂上提供博士前培训,
实验室和科学界在设计、操作和定量表征方面的作用
生物分子,细胞和组织,特别强调这些技术的翻译及其
在生物技术产业中的发展。培训活动的重点是加强和多样化
我们的生物技术工作队伍,并准备下一代领导人谁将开拓新兴的新
生物药物开发、组织工程、基因和细胞治疗等领域。参与
博士预科生必须符合以下标准:(1)进行研究,
(2)具有跨学科性质,是创新生物技术发展的核心;(3)至少
两名CBTE教师,一名来自生物医学科学,一名来自工程,在他们的博士论文
委员会;(3)出席每月工作进展学生研讨会系列;(4)完成工程
和生物医学科学课程,提供生物分子和组织工程的广度;(5)完成
四个学期的跨学科CBTE研讨会系列信贷,包括专门会议,
(6)参加为期三个月的工业生物技术实习;(7)参加
年度CBTE杰出讲座和研讨会;(8)参加定期安排的生物技术-
重点职业发展研讨会和讲习班;以及(9)接受负责任行为的培训
严谨性和可重复性。该跨学科培训计划包括37名教师,
校园,有22名来自普拉特工程学院的教师和15名来自非工程领域的教师,
包括5名在艺术与科学的Trinity学院,10名在基础医学科学和临床
杜克大学医学中心的部门。在过去的26年里,共有116名学生
接受生物分子和组织工程的博士前培训。我们的大多数学员
已获得生物技术行业领导者的职位,包括新公司的联合创始人
和生物技术新领域的先驱者,而其他人则在学术,医学或
政府的随着时间的推移,我们计划的一个特点是学员群体的多样性不断增加。
总的来说,这些活动无疑增加了我们受训人员的教育和准备价值
在生物技术行业和其他领域的职业生涯,正如我们广泛的业绩记录所证明的那样,
和定量结果测量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Charles A. Gersbach其他文献
Pulling the genome in opposite directions to dissect gene networks
- DOI:
10.1186/s13059-018-1425-1 - 发表时间:
2018-03-26 - 期刊:
- 影响因子:9.400
- 作者:
Charles A. Gersbach;Rodolphe Barrangou - 通讯作者:
Rodolphe Barrangou
Jumping at the chance for precise DNA integration
急于抓住精确 DNA 整合的机会
- DOI:
10.1038/s41587-019-0210-3 - 发表时间:
2019-08-01 - 期刊:
- 影响因子:41.700
- 作者:
Jennifer B. Kwon;Charles A. Gersbach - 通讯作者:
Charles A. Gersbach
577. Inducible Regulation of Runx2-Stimulated Osteogenesis
- DOI:
10.1016/j.ymthe.2006.08.650 - 发表时间:
2006-01-01 - 期刊:
- 影响因子:
- 作者:
Charles A. Gersbach;Joseph M. Le Doux;Robert E. Guldberg;Andres J. Garcia - 通讯作者:
Andres J. Garcia
Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER
使用 CLEANSER 在单细胞 CRISPR 筛选中对环境 gRNA 进行表征和生物信息学筛选
- DOI:
10.1016/j.xgen.2025.100766 - 发表时间:
2025-02-12 - 期刊:
- 影响因子:9.000
- 作者:
Siyan Liu;Marisa C. Hamilton;Thomas Cowart;Alejandro Barrera;Lexi R. Bounds;Alexander C. Nelson;Sophie F. Dornbaum;Julia W. Riley;Richard W. Doty;Andrew S. Allen;Gregory E. Crawford;William H. Majoros;Charles A. Gersbach - 通讯作者:
Charles A. Gersbach
Genome engineering: a new approach to gene therapy for neuromuscular disorders
基因组工程:一种针对神经肌肉疾病的基因治疗新方法
- DOI:
10.1038/nrneurol.2017.126 - 发表时间:
2017-09-29 - 期刊:
- 影响因子:33.100
- 作者:
Christopher E. Nelson;Jacqueline N. Robinson-Hamm;Charles A. Gersbach - 通讯作者:
Charles A. Gersbach
Charles A. Gersbach的其他文献
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{{ truncateString('Charles A. Gersbach', 18)}}的其他基金
Epigenome Editing Technologies for Treating Diverse Disease
用于治疗多种疾病的表观基因组编辑技术
- 批准号:
9810824 - 财政年份:2019
- 资助金额:
$ 53.05万 - 项目类别:
Epigenome Editing Technologies for Treating Diverse Disease
用于治疗多种疾病的表观基因组编辑技术
- 批准号:
10214461 - 财政年份:2019
- 资助金额:
$ 53.05万 - 项目类别:
Epigenome Editing Technologies for Treating Diverse Disease
用于治疗多种疾病的表观基因组编辑技术
- 批准号:
9973203 - 财政年份:2019
- 资助金额:
$ 53.05万 - 项目类别:
Epigenome Editing Technologies for Treating Diverse Disease
用于治疗多种疾病的表观基因组编辑技术
- 批准号:
10438803 - 财政年份:2019
- 资助金额:
$ 53.05万 - 项目类别:
CRISPR/Cas9-Based Gene Editing for the Correction of Duchenne Muscular Dystrophy
基于 CRISPR/Cas9 的基因编辑用于纠正杜氏肌营养不良症
- 批准号:
9888311 - 财政年份:2016
- 资助金额:
$ 53.05万 - 项目类别:
In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice
使用基于 CRISPR 的组蛋白乙酰转移酶转基因小鼠进行体内表观基因组编辑
- 批准号:
9132500 - 财政年份:2016
- 资助金额:
$ 53.05万 - 项目类别:
In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic
使用基于 CRISPR 的转基因组蛋白乙酰转移酶进行体内表观基因组编辑
- 批准号:
9895699 - 财政年份:2016
- 资助金额:
$ 53.05万 - 项目类别:
CRISPR/Cas9-Based Gene Editing for the Correction of Duchenne Muscular Dystrophy
基于 CRISPR/Cas9 的基因编辑用于纠正杜氏肌营养不良症
- 批准号:
9237199 - 财政年份:2016
- 资助金额:
$ 53.05万 - 项目类别:
Scaffold-Mediated Gene Delivery for Engineering of Osteochondral Tissues
用于骨软骨组织工程的支架介导的基因传递
- 批准号:
9069429 - 财政年份:2015
- 资助金额:
$ 53.05万 - 项目类别:
Scaffold-Mediated Gene Delivery for Engineering of Osteochondral Tissues
用于骨软骨组织工程的支架介导的基因传递
- 批准号:
8815847 - 财政年份:2015
- 资助金额:
$ 53.05万 - 项目类别:
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