Elucidating the role of mast cell tryptases in chronic obstructive pulmonary disease and Crohn's disease

阐明肥大细胞类胰蛋白酶在慢性阻塞性肺病和克罗恩病中的作用

• 批准号: nhmrc : 1023131
• 负责人: A/Pr Brian Oliver
• 金额: $ 41.39万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-role-mast-crohns-disease/110247
• 关键词: Elucidating; role; mast; cell; tryptases

Smoking leads to inflammation that causes emphysema and inflammation in the lung and gut, which are major health problems. Once induced, there is a progressive decline in health and there are no effective treatments. Particular proteins and small genes have been discovered that control inflammation in these diseases. We may be able to control these proteins/genes and stop the progression of emphysema and gut inflammation. This project may lead to a completely new way of preventing and treating these diseases.

吸烟会导致炎症，从而导致肺气肿以及肺部和肠道炎症，这是主要的健康问题。一旦诱发，健康状况就会逐渐恶化，并且没有有效的治疗方法。已经发现控制这些疾病中炎症的特殊蛋白质和小基因。我们也许能够控制这些蛋白质/基因并阻止肺气肿和肠道炎症的进展。该项目可能会带来一种预防和治疗这些疾病的全新方法。