Mechanisms of impaired bronchodilator response associated with fatty acid intake in obese asthma

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Obese asthmatics typically have a high dietary fat intake, which reduces the efficacy of their asthma medications. We will determine which types of dietary fat affect asthma medications. We will also determine which asthma medications are affected by a high fat load. Finally, we will examine the mechanisms by which fatty acids affect the efficacy of asthma medications. This is will inform new treatment options for managing the many obese asthmatics who are not able to achieve weight loss.