Mechanisms of impaired bronchodilator response associated with fatty acid intake in obese asthma

肥胖哮喘中与脂肪酸摄入相关的支气管扩张剂反应受损的机制

• 批准号: nhmrc : GNT1081355
• 负责人: A/Pr Brian Oliver
• 金额: $ 66.85万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-impaired-bronchodilator-obese-asthma/1345396
• 关键词: Mechanisms; impaired; bronchodilator; response; associated

Obese asthmatics typically have a high dietary fat intake, which reduces the efficacy of their asthma medications. We will determine which types of dietary fat affect asthma medications. We will also determine which asthma medications are affected by a high fat load. Finally, we will examine the mechanisms by which fatty acids affect the efficacy of asthma medications. This is will inform new treatment options for managing the many obese asthmatics who are not able to achieve weight loss.

肥胖哮喘患者通常膳食脂肪摄入量较高，这会降低哮喘药物的疗效。我们将确定哪些类型的膳食脂肪会影响哮喘药物。我们还将确定哪些哮喘药物会受到高脂肪负荷的影响。最后，我们将研究脂肪酸影响哮喘药物疗效的机制。这将为管理许多无法减肥的肥胖哮喘患者提供新的治疗选择。