HIGH INTENSITY LIGHT THERAPY IN ALZHEIMER'S DISEASE

阿尔茨海默病的高强度光疗法

• 批准号: 6512080
• 负责人: PHILIP D SLOANE
• 金额: $ 44.6万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6512080
• 关键词: Alzheimer's disease; anxiety; biosensor device; body temperature; circadian rhythms; cognition; computer assisted diagnosis; dementia; depression; human old age (65+); human subject; human therapy evaluation; light intensity; nervous system disorder therapy; nursing homes; outcomes research; patient oriented research; phototherapy; quality of life; radiation therapy dosage; seasonal affective disorder; sleep; wakefulness

DESCRIPTION (APPLICANT'S ABSTRACT): The care of persons with Alzheimer's disease and related dementias (AD) is a prevalent, costly, and growing issue, particularly for long-term care settings, where nearly 1.5 million persons with AD reside. Among the most troublesome management issues in AD are a tried of interrelated problems-sleep/wake disorders, depressive symptoms, and agitation. Current management of these conditions relies extensively on psychoactive medications, which have limited effectiveness and significant adverse effects. Demonstration of an effective, low-risk alternative treatment could have a favorable impact on long-term care nationwide. One promising alternative, high intensity light, has been demonstrated to produce biochemical and physiological effects on the systems that mediate these behaviors, and to have produced significant improvement in pilot and preliminary studies. The proposed project is a clinical trial with crossover, of the effect of high intensity, low glare, ambient daytime light on sleep/wake patterns, depressive symptoms, and agitation in nursing home residents with AD. It will be conducted in a licensed skilled nursing facility within a state psychiatric hospital, which manages 45 residents with AD. It will employ a 4 treatment, 12 period crossover design, with the treatments consisting of a) morning high intensity light, b) evening high intensity light, c) full day high intensity light, and d) the control (preexisting) lighting. The intervention (applied separately to each of 3 wards) will consist of fixtures that produce even, non-glare light averaging 2500-3000 lux in all public areas of the facility. Sleep/activity will be measured using wrist motion sensors; depressive symptoms will be measured using the Cornell Depression Index and the Philadelphia Geriatric Center Affect Rating Scale; and agitation will be measured using computer-assisted direct observations and the Cohen-Mansfield Agitation Inventory. Light exposure will be documented using wrist photocells. Secondary outcomes will include staff depression and reported hassles. Data collection will continue for one year to allow analyses to adjust for seasonal differences in outdoor light levels.

描述（申请人摘要）：阿尔茨海默病患者的护理 疾病及相关痴呆（AD）是一个普遍存在、成本高昂且日益严重的问题， 尤其是长期护理机构，那里有近 150 万人患有 AD 驻留。 AD 中最麻烦的管理问题之一是尝试 相互关联的问题——睡眠/觉醒障碍、抑郁症状和烦躁。 目前对这些病症的治疗很大程度上依赖于精神活性药物 药物治疗，其效果有限且副作用显着。 证明一种有效、低风险的替代疗法可能会产生 对全国长期护理产生积极影响。一种有前途的替代方案，高 强度光，已被证明可以产生生化和生理学 对介导这些行为的系统产生影响，并产生 试点和初步研究取得重大进展。 拟议的项目是一项具有交叉的临床试验，其效果高 强度、低眩光、影响睡眠/觉醒模式的日间环境光、抑郁 患有 AD 的疗养院居民的症状和躁动。将会进行 在州立精神病院内有执照的熟练护理机构中， 该诊所管理着 45 名患有 AD 的居民。它将采用 4 次治疗、12 个周期 交叉设计，治疗方法包括：a) 早晨高强度 光，b) 夜间高强度光，c) 全天高强度光，以及 d) 控制（已有的）照明。干预措施（单独应用于 3 个病房中的每个病房都将配备产生均匀、不眩光的光线的灯具 设施所有公共区域的平均照度为 2500-3000 勒克斯。睡眠/活动 将使用手腕运动传感器进行测量；将会出现抑郁症状 使用康奈尔抑郁指数和费城老年人指数进行测量 中心影响评定量表；和搅拌将使用测量 计算机辅助直接观察和科恩-曼斯菲尔德搅拌 存货。将使用手腕光电管记录曝光情况。中学 结果将包括员工抑郁和报告的麻烦。数据收集 将持续一年，以便分析能够根据季节差异进行调整 在室外光线水平下。