Elucidation of the gene regulatory networks that cause Alzheimer's disease in Down Syndrome;

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People with Down syndrome have an extra chromosome 21 and all develop Alzheimer's disease. We are able to delete different parts of chromosome 21 in Down syndrome stem cells and turn these cells into the two main cell types of the brain. By comparing the occurrence of Alzheimer disease with gene expression changes in these gene-edited cell types we can identify the gene-regulatory pathways that cause Alzheimer's disease in Down syndrome and identify novel therapeutic targets for sporadic Alzheimer's disease.