STATISTICAL COORDINATING CENTER FOR THE BREAST CANCER SU

苏乳腺癌统计协调中心

• 批准号: 6514500
• 负责人: WILLIAM E BARLOW
• 金额: $ 71.04万
• 依托单位: KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-10 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6514500
• 关键词: breast neoplasms; cancer information system; clinical research; data collection; data collection methodology /evaluation; data management; human data; mammography; method development; outcomes research; statistical service /center; statistics /biometry

The Statistical Coordinating Center's (SCC) primary functions are to support the collection and analysis of data for the Breast Cancer Surveillance Consortium, develop and implement new statistical methodology that will characterize the process of mammography, and provide scientific guidance in the development of publications. The major goals of the Consortium are to provide population-based information on the performance of breast cancer screening in the community, improve the process of tumor detection, examine the role of practice patterns and biological factors on outcomes, and evaluate the efficacy of mammography in reducing breast cancer morbidity and mortality. In the last four years the SCC has established a standardized data collection system, constructed standardized questions, analyzed 1.5 million mammograms for inclusion in three papers underway, and assessed reader variability in interpretation of mammograms. In the next five years, the SCC will do the following: (1) Implement methods that continue to improve comparability of data across sites by improving quality control and maintaining standardized data collection instruments; (2) Maintain a data management system that facilitates pooled analyses and rapid development of new projects; (3) Conduct analyses of the outcomes of screening and symptomatic mammography to identify predictors and sources of variation across sites; (4) Develop statistical methods that allow for modeling of hierarchical, longitudinal data with covariates at the site, radiologist, or woman level; (5) Develop methods to evaluate the efficacy of the BIRADS 0 (incomplete) on outcomes; (6) Evaluate accuracy in a population undergoing repeat mammography; and (7) Provide scientific leadership and dissemination by maintaining a Consortium Web page, conducting annual meetings of the Data Managers and Statisticians, conducting site visits, and participating in the scientific leadership by developing proposals, conducting analyses, and publishing the results.

统计协调中心 (SCC) 的主要职能是支持乳腺癌监测联盟的数据收集和分析，开发和实施新的统计方法来描述乳房 X 光检查过程，并为出版物的开发提供科学指导。 该联盟的主要目标是提供有关社区乳腺癌筛查表现的基于人群的信息，改进肿瘤检测过程，检查实践模式和生物因素对结果的作用，并评估乳房X光检查在降低乳腺癌发病率和死亡率方面的功效。在过去四年中，SCC 建立了标准化数据收集系统，构建了标准化问题，分析了 150 万张乳房 X 光照片以纳入正在撰写的三篇论文中，并评估了读者对乳房 X 光照片解读的差异性。 未来五年，SCC将开展以下工作：（1）通过改进质量控制和维护标准化数据收集工具，实施持续提高跨站点数据可比性的方法； (2) 维护数据管理系统，促进新项目的汇总分析和快速开发； (3) 对筛查和症状性乳房X光检查的结果进行分析，以确定不同地点的预测因素和变异来源； (4) 开发统计方法，允许对具有现场、放射科医生或女性级别的协变量的分层、纵向数据进行建模； (5) 制定方法来评估 BIRADS 0（不完整）对结果的功效； (6) 评估接受重复乳房X光检查的人群的准确性； (7) 通过维护联盟网页、召开数据管理者和统计学家年度会议、进行实地考察以及通过制定提案、进行分析和发布结果来参与科学领导，提供科学领导和传播。